PMID: 16538118Mar 16, 2006Paper

Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver

European Journal of Gastroenterology & Hepatology
Emanuel BurriRémy Meier

Abstract

Liver-cell adenomas are benign lesions of the liver occurring predominantly in young women. Hepatocellular carcinomas in most of the cases arise in a cirrhotic liver during the fifth or sixth decade. We describe the case of a 40-year-old woman in whom work-up for epigastric pain revealed a peptic ulcer and a large hepatic mass. Tests for chronic liver diseases were negative. Imaging findings and biopsy specimens of the tumour were inconclusive. The tumour was surgically removed and a hepatocellular carcinoma arising within a liver-cell adenoma in a non-cirrhotic liver was found. Malignant transformation of liver-cell adenoma has only been reported in a few case reports. Mechanisms of transformation remain unclear. The imaging findings as well as histological features are presented in detail and the literature is discussed.

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Citations

Dec 7, 2007·Der Pathologe·M Evert, F Dombrowski
Jul 10, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Siong-Seng LiauEmmanuel Huguet
May 22, 2013·International Journal of Hepatology·Paulette Bioulac-SageCharles Balabaud
Apr 20, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay KakarLinda D Ferrell
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Mar 10, 2016·Gastroenterología y hepatología·José M RamiaRoberto de la Plaza
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Jun 23, 2009·The Korean Journal of Internal Medicine·Dong Hwan KimDo Young Kim
Oct 1, 2014·Hepatic Oncology·Christine SempouxPaulette Bioulac-Sage
Sep 29, 2020·Clinical Case Reports·Haythem YacoubNadia Maamouri

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Related Concepts

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Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

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