Hepatocellular carcinoma in Australia 1982-2014: Increasing incidence and improving survival

Liver International : Official Journal of the International Association for the Study of the Liver
Michael C WallaceGary P Jeffrey

Abstract

There is a paucity of accurate and current data on hepatocellular carcinoma (HCC) trends in incidence and survival in developed countries. We performed an Australia-wide assessment of HCC epidemiology across a 33-year time span aiming to accurately describe changes in incidence and survival. Cases of HCC from 1982 to 2014 were identified via the Australian Cancer Database (ACD). Trends in incidence rates were explored using piecewise linear regression. Survival was compared by Kaplan-Meier survival curves and 1-, 3- and 5-year survival probabilities by year of diagnosis. Age-adjusted HCC incidence rate increased from 1.38 per 100 000 (95% CI: 1.34-1.43) in 1982 to 4.96 per 100 000 (95% CI: 4.89-5.03, P < 0.001) in 2014 with an average annual percentage increase of 4.46% (95% CI: 4.24%-4.69%). The highest incidence rate in 2014 was in those aged 75-79 (24.31 per 100 000; 95% CI: 19.50-29.12). Almost 80% of cases across the period were men who had significantly higher age-adjusted incidence rates in 2014 than women (8.55 per 100 000 [95% CI: 8.42-8.68] vs 1.65 per 100 000 [95% CI: 1.60-1.70]; P < 0.001). A hepatitis C (HCV) birth cohort effect was identified and associated with rapid increases in HCC incidence when members of the...Continue Reading

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Citations

Mar 6, 2019·Digestive Diseases and Sciences·Mehmet SayinerZobair M Younossi
Apr 9, 2019·Australian and New Zealand Journal of Public Health·Fiona CockerBarbara de Graaff
Feb 10, 2020·Journal of Gastroenterology and Hepatology·Michael C WallaceGary P Jeffrey
Sep 10, 2020·Journal of Gastrointestinal Cancer·Ryan D HirschAmanda J Nicoll
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Luis Calzadilla Bertot, Leon A Adams
Dec 20, 2019·Journal of Viral Hepatitis·Yinzong XiaoMargaret E Hellard
Dec 15, 2020·The Medical Journal of Australia·John S LubelNick Shackel
Feb 21, 2021·The Medical Journal of Australia·Jessica HowellJoshua S Davis
Feb 26, 2021·Internal Medicine Journal·John S LubelNichols A Shackel
Jul 3, 2021·International Journal of Environmental Research and Public Health·Chengyu LiuZheng Chang

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