Hepatocellular carcinoma in black-tailed prairie dogs (Cynomys ludivicianus): tumor morphology and immunohistochemistry for hepadnavirus core and surface antigens

Veterinary Pathology
M M GarnerB C Tennant

Abstract

From 1994 to 2002, tissues from 61 prairie dogs were submitted to Northwest ZooPath for histopathology. Of these, 12 (20%) had hepatocellular carcinoma (HCC). Three were pets submitted from private veterinary practices. The others were submitted from zoos in the United States. All were adults, ranging from young adult to 7 years of age, with average age of 5.1 years. The most common clinical signs were weight loss, lethargy, palpable abdominal mass, and respiratory difficulty. All tumors were well-differentiated HCCs in which four histologic patterns were recognized. The trabecular pattern was predominant in nine tumors, and the pseudoglandular pattern was predominant in two tumors. The pelioid pattern was also represented in eight tumors. A papillary pattern was present in one case. In seven cases vacuolar change resembling lipidosis was present in the neoplastic hepatocytes of both primary and metastatic tumors. Anaplasia was mild to moderate in most tumors, but a marked degree of anaplasia was noted in the metastatic foci of the case with papillary differentiation. Metastasis to lung was noted in five cases. One of these also had metastasis to the spleen, and another had metastasis to heart and mediastinum. In two cases ther...Continue Reading

References

Jan 1, 1975·Journal of Clinical Pathology·K P DeodharP J Scheuer
Nov 1, 1992·Journal of Gastroenterology and Hepatology·W S Robinson
Jul 1, 1992·Cancer Causes & Control : CCC·A MellemgaardJ H Olsen
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P L MarionW S Robinson
Oct 1, 1982·Journal of Wildlife Diseases·A WoolfB Tennant
Jul 1, 1996·Journal of Virology·P TestutM A Buendia
Sep 1, 1996·The Journal of Veterinary Medical Science·Y UneY Saito
Dec 16, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R JacobB C Tennant
Jun 15, 2001·ILAR Journal·B C Tennant, J L Gerin
Feb 19, 2004·Journal of the National Cancer Institute·Asad UmarSudhir Srivastava

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Citations

Aug 18, 2009·Journal of Comparative Pathology·F J SalgueroS Lesellier
Dec 17, 2015·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Stephen M ChegeArshad Toosy
Jun 23, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Pamela MouserTsang Long Lin
Jan 14, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Xi Jun HeHiroyuki Nakayama
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Kelsey M McClureElizabeth E Hammond

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Methods Mentioned

BETA
transfecting

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