Hepatocellular carcinoma in hemodialysis patients

Oncotarget
Chern-Horng LeeTzung-Hai Yen

Abstract

We investigated the rates and predictors of mortality in hepatocellular carcinoma (HCC) patients who were or were not undergoing long-term hemodialysis. The participants in this retrospective observational study were 1298 HCC patients (60.0 ± 12.1 years old, 72% male), of whom 172 were undergoing hemodialysis and 1126 were not. HCC patients on hemodialysis exhibited a higher hepatitis C virus carrier rate (49.4% versus 39.3%, P = 0.012), lower hepatitis B virus carrier rate (37.2% versus 58.3%, P < 0.001) and lower hepatitis B or C virus carrier rate (77.9% versus 89.3%, P < 0.001) than those not on hemodialysis. Serum alkaline phosphatase levels were higher in the hemodialysis than non-hemodialysis group (162.8 ± 141.1 u/l versus 124.6 ± 102.5 u/l, P < 0.001). By the end of the analysis, 32.0% of HCC patients on hemodialysis and 28.0% of those not on hemodialysis had died. Kaplan-Meier analysis confirmed that cumulative survival was poorer in HCC patients on hemodialysis (P = 0.004). In a multivariate Cox regression model, hemodialysis (P < 0.001), older age (P < 0.001) and advanced tumor stages (P < 0.001) were found to be risk factors for mortality. HCC patients on hemodialysis had a 2.036-fold greater chance of death than H...Continue Reading

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Citations

Jul 25, 2019·International Journal of Environmental Research and Public Health·Chern-Horng LeeTzung-Hai Yen
Oct 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Sunil TanejaHarbir S Kohli
Aug 18, 2020·Canadian Journal of Physiology and Pharmacology·Chen XiaohongXiang Fangfang
Jul 31, 2021·World Journal of Gastroenterology : WJG·Hsuan YehTzung-Hai Yen
Jul 25, 2021·Cancers·Fabrizio FabriziEzequiel Ridruejo

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS Statistics

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