Abstract
The aims of this study were to define the clinical characteristics of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in young adult patients without cirrhosis and to evaluate the efficacy of interferon (IFN) therapy on HCC recurrence. Of 187 patients with HBV-related HCC treated at our hospital, 4 had no liver cirrhosis and were less than 30 years of age (10, 22, 23, and 26 years). At the time of diagnosis of HCC, all cases had antibody to hepatitis B e antigen (anti-HBe) and histological staging of nontumorous liver was F0 or F1, i.e., low-grade hepatitis. The mothers of all 4 young adult patients with HCC had HBV-related liver disease. Three cases developed recurrence of HCC. In these patients, long-term intermittent IFN therapy after reresection of HCC resulted in long-term survival without recurrence for more than 3 years of follow-up. (1) Young adult patients with HCC are positive for anti-HBe, lack cirrhosis, and the route of infection seems to be mother-to-infant transmission. Transplacental transmission of HBV and HBV DNA integration into the cellular genomic DNA during fetal life is a possible explanation of HBV-related hepatocarcinogenesis in young adults; and (2) long-term IFN therapy seems to be usef...Continue Reading
Citations
Apr 14, 2005·Journal of Hepatology·Ruben Bonilla Guerrero, Lewis R Roberts
Oct 29, 2013·BMC Genomics·Hsei-Wei WangJaw-Ching Wu
Mar 5, 2013·World Journal of Surgical Oncology·Shingo ShimadaAkinobu Taketomi
Apr 5, 2013·PloS One·Lishuai QuXizhong Shen
Nov 18, 2008·Journal of Gastroenterology·Pik-Eu ChangChee-Kiat Tan
Feb 20, 2007·Journal of Viral Hepatitis·F-C TsaiD-S Chen
Sep 20, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Edward Tabor
Jan 11, 2007·Journal of Viral Hepatitis·C-L LinD-S Chen
Sep 15, 2011·Journal of Viral Hepatitis·J-X ZhengF Wang
Mar 23, 2012·Journal of Digestive Diseases·Qin WangSpiros P Hiotis
Jan 30, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hongli YanShuhan Sun
Oct 4, 2016·Journal of Hepatology·Maneerat ChayanupatkulFasiha Kanwal
Oct 18, 2016·Cancer Medicine·Hitoshi TajiriYasuhito Tanaka
Aug 24, 2006·Intervirology·Hitomi SezakiHiromitsu Kumada
Jul 23, 2009·Journal of Medical Virology·Raquel VianaMichael C Kew
Dec 17, 2010·World Journal of Hepatology·Michael C Kew
Jul 4, 2019·European Journal of Gastroenterology & Hepatology·Yu Jung HwanJin-Woo Lee
Oct 28, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroshi YotsuyanagiUNKNOWN Japanese adolescent HBV-HCC study group
Aug 28, 2020·Cancer Management and Research·Jianxing ZengJingfeng Liu
Mar 16, 2006·Current Hematology Reports·David Green
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard J Epstein, Thomas W Leung