Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection

Journal of Gastroenterology
Hitomi SezakiHiromitsu Kumada

Abstract

The aims of this study were to define the clinical characteristics of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in young adult patients without cirrhosis and to evaluate the efficacy of interferon (IFN) therapy on HCC recurrence. Of 187 patients with HBV-related HCC treated at our hospital, 4 had no liver cirrhosis and were less than 30 years of age (10, 22, 23, and 26 years). At the time of diagnosis of HCC, all cases had antibody to hepatitis B e antigen (anti-HBe) and histological staging of nontumorous liver was F0 or F1, i.e., low-grade hepatitis. The mothers of all 4 young adult patients with HCC had HBV-related liver disease. Three cases developed recurrence of HCC. In these patients, long-term intermittent IFN therapy after reresection of HCC resulted in long-term survival without recurrence for more than 3 years of follow-up. (1) Young adult patients with HCC are positive for anti-HBe, lack cirrhosis, and the route of infection seems to be mother-to-infant transmission. Transplacental transmission of HBV and HBV DNA integration into the cellular genomic DNA during fetal life is a possible explanation of HBV-related hepatocarcinogenesis in young adults; and (2) long-term IFN therapy seems to be usef...Continue Reading

Citations

Apr 14, 2005·Journal of Hepatology·Ruben Bonilla Guerrero, Lewis R Roberts
Sep 20, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Edward Tabor
Jan 30, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hongli YanShuhan Sun
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