Hepatocellular carcinoma induction in LEC rats by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Japanese Journal of Cancer Research : Gann
H SoneMinako Nagao

Abstract

A food-borne heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), induces hepatocellular carcinomas (HCCs) in F344 male rats at an incidence of 95%, when fed in the diet at 400 ppm for 61 weeks. In this study, the effect of a low dose of MeIQx was examined in Long-Evans with cinnamon-like coat color (LEC) rats, which have a mutation in Atp7b and suffer from hereditary hepatitis and HCCs, with high levels of copper accumulation in the liver. Rats of the LEC and Long-Evans with agouti coat color (LEA) sibling lines were given a diet containing 40 ppm MeIQx from the age of 23 weeks to 63 weeks, for a total administration period of 40 weeks. In LEC rats, HCCs were observed in 8/8 animals administered MeIQx, and 2/8 rats receiving a normal diet. The number of HCCs per rat (mean +/- SD) was 2.8 +/- 2.0 and 0.3 +/- 0.5, respectively. In the LEA rats, however, no tumors were induced by administration of MeIQx. These results indicate that damaged liver associated with compensatory cell proliferation is much more susceptible to chemical hepatocarcinogens, including MeIQx, than the normal liver.

References

Jul 1, 1991·Journal of Gastroenterology and Hepatology·K KawanoT Natori
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·I SaitoY Ohta
Apr 1, 1989·Journal of Clinical Gastroenterology·J PolioC E Atterbury
Jan 1, 1989·Japanese Journal of Cancer Research : Gann·Y FujimotoM Nagao
Jun 1, 1988·Trends in Pharmacological Sciences·T Sugimura
Nov 1, 1987·The Journal of Heredity·M C YoshidaM Mori
Nov 11, 1981·Nucleic Acids Research·S E BryanK J Hardy
Aug 15, 1994·Cancer Letters·H KushidaM Nagao
Nov 30, 1993·Biochemical and Biophysical Research Communications·Y YamaguchiJ D Gitlin
May 1, 1993·Japanese Journal of Cancer Research : Gann·F YamamotoS Nishimura
Apr 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K SoneM Nagao

❮ Previous
Next ❯

Citations

Nov 14, 1997·Trends in Genetics : TIG·F ForozanO P Kallioniemi
Jun 17, 2020·Archives of Toxicology·Andrea HartwigGerhard Eisenbrand

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.