Hepatocellular carcinoma Liver Imaging Reporting and Data Systems treatment response assessment: Lessons learned and future directions.

World Journal of Hepatology
Anum AslamMishal Mendiratta-Lala

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of morbidity and mortality worldwide, with rising clinical and economic burden as incidence increases. There are a multitude of evolving treatment options, including locoregional therapies which can be used alone, in combination with each other, or in combination with systemic therapy. These treatment options have shown to be effective in achieving remission, controlling tumor progression, improving disease free and overall survival in patients who cannot undergo resection and providing a bridge to transplant by debulking tumor burden to downstage patients. Following locoregional therapy (LRT), it is crucial to provide treatment response assessment to guide management and liver transplant candidacy. Therefore, Liver Imaging Reporting and Data Systems (LI-RADS) Treatment Response Algorithm (TRA) was created to provide a standardized assessment of HCC following LRT. LI-RADS TRA provides a step by step approach to evaluate each lesion independently for accurate tumor assessment. In this review, we provide an overview of different locoregional therapies for HCC, describe the expected post treatment imaging appearance following treatment, and review the LI-RADS TRA with guidance for ...Continue Reading

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Citations

Apr 4, 2021·International Journal of Environmental Research and Public Health·Vincenza GranataFrancesco Izzo
Jun 10, 2021·Abdominal Radiology·Roopa RamMishal Mendiratta-Lala
Jun 14, 2021·Abdominal Radiology·Marielia GerenaAnia Kielar
Sep 25, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Frank H MillerRobert J Lewandowski

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Methods Mentioned

BETA
surgical resection

Software Mentioned

RADS TRA
LI
EASL
TARE
RADS
mRECIST

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