Hepatocellular carcinoma metastatic to skin: diagnostic utility of antihuman hepatocyte antibody in combination with albumin in situ hybridization

Journal of Cutaneous Pathology
Angela J WoodIftikhar Ahmed

Abstract

Cutaneous metastases from hepatic neoplasms are rare. Histologic features of hepatocellular carcinoma (HCC) are often poorly differentiated, hindering accurate diagnosis on routine examination by hematoxylin-eosin stain. Antihuman hepatocyte antibody is highly sensitive for HCC but can be strongly expressed in other adenocarcinomas. Albumin in situ hybridization (ISH) is highly specific and sensitive for HCC; in combination with antihuman hepatocyte antibody, it has a diagnostic sensitivity approaching 100%. To our knowledge, the combination of antihuman hepatocyte antibody and albumin ISH has not previously been examined in the context of cutaneous HCC. We present histologic findings and results of ancillary studies for three patients with metastatic HCC. These patients had a poorly differentiated cytokeratin-positive cutaneous neoplasm. All three cases were evaluated with antihuman hepatocyte antibody and albumin ISH. Neoplastic cells were strongly positive for antihuman hepatocyte antibody, and ISH detected albumin messenger RNA in nearly 100% of the neoplastic cells in all three cases. The combination of antihuman hepatocyte antibody and albumin ISH is highly sensitive and specific for HCC metastatic to skin and is useful i...Continue Reading

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Citations

Sep 4, 2012·Journal of Maxillofacial and Oral Surgery·Tadashi Terada
May 24, 2012·The American Journal of Dermatopathology·Inmaculada AlcarazLuis Requena
Dec 1, 2011·International Journal of Dermatology·Jenny A MandellKaren J Haglof
Oct 24, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Neil PatelLouise Fearfield
Feb 25, 2021·Nuclear Medicine Communications·Moheieldin M AbouziedMohammed Al Qahtani

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