Hepatocellular carcinoma: overcoming challenges in disease management

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Robert G Gish

Abstract

Hepatocellular carcinoma is the third most frequent cause of death from cancer and the eighth most commonly occurring cancer in the world. In the United States, hepatocellular carcinoma appears to be increasing along with evolution of chronic hepatitis infection, especially in the immigrant population, a major risk group. A disease of multifactorial etiology, hepatocellular carcinoma confers many management challenges. Hepatocarcinogenesis is a multistep process involving different genetic alterations that ultimately lead to malignant transformation of the hepatocyte. Early hepatocellular carcinoma is characteristically silent and slow growing with few symptoms until late in disease. Early and accurate diagnosis of hepatic tumors relies on clinical suspicion, screening protocols, serologic testing, radiologic imaging, and tissue confirmation. Lack of clinically validated biomarkers and clinical identification of hepatocellular carcinoma at advanced disease make diagnosis and treatment difficult. Advances in computed tomography and magnetic resonance imaging have markedly increased the sensitivity and specificity of testing, yet they are still flawed with a relatively high false-positive rate. Several surgical and nonsurgical th...Continue Reading

References

Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J L RaoulM Gosselin
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Collier, M Sherman
Aug 26, 1998·American Journal of Clinical Oncology·A PawarodeY Z Patt
Nov 26, 1998·Journal of Cancer Research and Clinical Oncology·J A del OlmoJ M Rodrigo
Jun 11, 1999·Annals of Surgery·Y FongL H Blumgart
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Oct 13, 2000·Journal of the American College of Surgeons·K HanazakiJ Amano
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J M LlovetJ Bruix
Feb 24, 2001·Clinics in Liver Disease·H B el-Serag
Apr 13, 2001·Seminars in Oncology·J O Ogunbiyi
Nov 10, 2001·Journal of Hepato-biliary-pancreatic Surgery·S AriiM Imamura
Jan 16, 2002·Gastrointestinal Endoscopy·Mohamad A Eloubeidi, Miguel R Arguedas
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi Bruix, Josep M Llovet
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chung-Mau LoJohn Wong
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mindie H NguyenEmmet B Keeffe
Oct 2, 2002·Journal of Vascular and Interventional Radiology : JVIR·William S Rilling, Alain Drooz
Oct 3, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts
Mar 26, 2003·The American Journal of Gastroenterology·Miguel R ArguedasMichael B Fallon
Apr 15, 2003·Gut·S D Ryder, UNKNOWN British Society of Gastroenterology
Nov 19, 2003·Annals of Internal Medicine·Hashem B El-SeragKatherine A McGlynn
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jean M RegimbeauJacques Belghiti
Mar 30, 2004·The British Journal of Surgery·S WildiP-A Clavien
May 27, 2004·World Journal of Gastroenterology : WJG·Pisit TangkijvanichYong Poovorawan
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y Yao, John P Roberts
Oct 16, 2004·Clinics in Liver Disease·Morris Sherman
Oct 28, 2004·Gastroenterology·Leonard B Seeff
Oct 28, 2004·Gastroenterology·Russell H WiesnerDavid C Mulligan
Oct 28, 2004·Gastroenterology·Timothy R MorganM Mazen Jamal
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Margarita SalaUNKNOWN Barcelona Clínic Liver Cancer Group

❮ Previous
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Citations

Feb 23, 2010·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·O A TimofeevaN A Setkov
Aug 1, 2007·Biomarkers in Medicine·Nikki P Y LeeJohn M Luk
Jan 8, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuling GanXinghua Song
Oct 7, 2014·Journal of Clinical Laboratory Analysis·Julien Marlet, Maguy Bernard
Apr 1, 2008·Surgical Oncology Clinics of North America·Travis KidnerYuman Fong
May 23, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Rosângela TeixeiraScott L Friedman
Jan 22, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mei-Chuan ChenChing-Shih Chen
Sep 12, 2013·BioMed Research International·Xin-xing WanDian-zheng Zhang
Aug 10, 2016·Apoptosis : an International Journal on Programmed Cell Death·Chatla SrinivasManika Pal Bhadra
Jul 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert G GishGerard T Kennealey
May 4, 2018·Alimentary Pharmacology & Therapeutics·C-L Lin, J-H Kao
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yen-Shen LuChing-Shih Chen
Mar 25, 2010·The Journal of Heredity·Craig B LoweDavid Haussler
Oct 4, 2016·Oncotarget·Zhen-Guang WangWei-Ping Zhou
Jun 12, 2013·Journal of Clinical Gastroenterology·Judith Meza-JuncoMichael B Sawyer
Jan 29, 2008·Journal of Clinical Gastroenterology·Mario StrazzaboscoSukru Emre
Jun 6, 2021·Digestive Diseases and Sciences·Vaishnavi BoppanaDenis M McCarthy
Sep 15, 2011·Journal of Proteome Research·Yong-Yook LeeSun-Il Hwang

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