Hepatocellular carcinoma p53 G > T transversions at codon 249: the fingerprint of aflatoxin exposure?

Environmental Health Perspectives
T Lasky, L Magder

Abstract

The molecular epidemiology of p53 mutations allows the possibility of correlating particular mutations with specific environmental carcinogens and establishing one step in the causal pathway between exposure to carcinogens and the development of cancer. A striking example is the G > T transversion at the third base pair of codon 249 observed in liver cancer patients possibly exposed to high levels of aflatoxins in their agricultural products. In this paper, we describe a systematic review of the literature and access the quality of the available data. We found methodologic limitations in the studies. In particular, the key independent variable, aflatoxin exposure, was not assessed in these studies, with the exception of one study that measured a marker of exposure. Instead, nationality, geographic residence, or geographic site of hospital were used as surrogate markers for exposure. Patients from areas with high aflatoxin levels were more likely to have p53 mutations than were patients from areas with low aflatoxin levels. In the group with p53 mutations, patients from areas with high aflatoxin levels had higher proportions of mutations with codon 249 G > T transversions. The differences in proportions with p53 mutations were s...Continue Reading

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Citations

Sep 7, 2013·Cancer Letters·Badr AlzahraniLionel W Hebbard
Jan 15, 2003·Clinical Microbiology Reviews·D M Kuhn, M A Ghannoum
Oct 31, 2009·Carcinogenesis·Christopher P Wild, Yun Yun Gong
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Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Christian HafnerArndt Hartmann
Mar 19, 2021·Applied Biochemistry and Biotechnology·Sushma S Murthy, T Bala Narsaiah

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