Hepatocellular carcinoma treatment: a comparative review of emerging growth factor receptor antagonists

Expert Opinion on Emerging Drugs
Su Jin Lee, Ho Yeong Lim

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Over the last decade, sorafenib has been the only available therapeutic option for advanced HCC, although regorafenib recently showed a survival benefit compared with placebo in a second-line setting. Areas covered: This review discusses key published and ongoing studies with targeted agents in HCC, molecular targets of HCC, the mechanism of resistance to sorafenib, and the role of biomarker-enriched clinical trials. Expert opinion: The multiplicity of drivers and the existence of substantial molecular heterogeneity limit the benefits of targeted therapies in HCC. Based on molecular biology developments, a few biomarker-enriched clinical trials that target candidate driver genes are ongoing, and the outcomes of these are highly anticipated. Poor availability of tumor tissue and tumor heterogeneity in patients with HCC make liquid biopsy a very attractive option, although this technique remains to be validated.

References

Jan 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J Y LjubimovaA A Demetriou
Jul 9, 1997·Biochemical and Biophysical Research Communications·C M SchmidtJ V Sitzmann
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ItoM Hori
Mar 10, 2001·Nature·L Chang, M Karin
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chung-Mau LoJohn Wong
Jan 10, 2003·Journal of Cellular Biochemistry·Yu-Wen Zhang, George F Vande Woude
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Jun 7, 2003·Trends in Cell Biology·Marta Rosário, Walter Birchmeier
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Woo Sung MoonAndrzej S Tarnawski
Aug 12, 2003·Oncogene·Timothy M BlockRobert Jordan
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hitoshi YoshijiHiroshi Fukui
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fikret SahinMichael Torbenson
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cédric CoulouarnSnorri S Thorgeirsson
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Aug 15, 2008·Cancer Research·Derek Y ChiangJosep M Llovet
Oct 22, 2008·Gastroenterology·Augusto VillanuevaJosep M Llovet
Nov 4, 2008·Journal of Hepatology·Kathleen LangDavid Thompson
May 12, 2009·Experimental Biology and Medicine·Carmen BerasainMatías A Avila
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew X ZhuRakesh K Jain
Sep 10, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rachel KasselYoung S Hahn
Nov 3, 2009·The Lancet Oncology·Donald PoonUNKNOWN Asian Oncology Summit
Dec 19, 2009·The Journal of Biological Chemistry·Xinle WuYang Li
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Livio TrusolinoPaolo M Comoglio
Dec 9, 2010·The Oncologist·Alan P VenookLaura Ladrón de Guevara
Dec 9, 2010·The Oncologist·Arun J SanyalRiccardo Lencioni
Mar 10, 2011·Nature Reviews. Clinical Oncology·Andrew X ZhuRakesh K Jain
May 4, 2011·Cancer·Andrew X ZhuDavid P Ryan
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Clinical Advances in Hematology & Oncology : H&O
Matthew R Skelton, Bert O'Neil
Journal of Clinical Gastroenterology
Jean K Lee, Ghassan K Abou-Alfa
Expert Opinion on Pharmacotherapy
Jan BestAlexander Dechêne
© 2022 Meta ULC. All rights reserved