Hepatocellular Carcinoma with Irregular Rim-Like Arterial Phase Hyperenhancement: More Aggressive Pathologic Features

Liver Cancer
Hyungjin RheeMyeong-Jin Kim

Abstract

The purpose of our study was to examine the histopathologic characteristics of hepatocellular carcinoma (HCC) with irregular rim-like arterial phase enhancement (IRE), which has been reported to be associated with more aggressive tumor behavior. We investigated 84 pathologically confirmed HCCs in 84 patients who underwent curative hepatic resection after gadoxetate-enhanced magnetic resonance imaging between January 2008 and February 2013. Two abdominal radiologists independently reviewed these images and classified HCCs into two categories: HCC showing IRE (IRE-HCC) and HCC showing hypoenhancement or diffuse arterial enhancement (non-IRE-HCC). Twenty-two HCCs were classified as IRE-HCCs, and 51 were classified as non-IRE-HCCs concordantly by both reviewers. The remaining 11 HCCs, on whose radiologic classifications the reviewers disagreed, were classified as HCCs with intermediate enhancement patterns. The HCC clinicopathologic characteristics and patient outcomes were then compared. IRE-HCCs showed more frequent microvascular invasion (91 vs. 35%), lower microvascular density (246.5 vs. 426.5/mm2), higher proportions of sinusoid-like microvascular pattern (55 vs. 0%) and macrotrabecular pattern (45 vs. 0%), and larger areas o...Continue Reading

Citations

Sep 2, 2018·Abdominal Radiology·Chansik An, Myeong-Jin Kim
Jun 10, 2021·Journal of Hepatocellular Carcinoma·Guilherme Moura CunhaClaude B Sirlin
Jul 11, 2021·Magnetic Resonance Imaging Clinics of North America·Silvia D ChangVictoria Chernyak
Aug 18, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ji Yoon MoonHo-Jeong Won

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