PMID: 7538016Mar 1, 1995Paper

Hepatocellular carcinoma

The Gastroenterologist
M Sherman

Abstract

Hepatocellular carcinoma (HCC) is among the 10 most common tumors in the world. However, incidence is not evenly distributed across the world. In many instances, the proximate cause for the tumor can be identified. Chronic hepatitis B infection is probably the most common cause, followed by chronic hepatitis C. Other important causes are alcoholic liver disease, hemochromatosis, alpha 1-antitrypsin deficiency, and other chronic liver diseases. Although proximate causes may be identifiable, pathogenesis remains uncertain. Factors that may be important include the presence of Aflatoxin B1 in food, genetic changes induced by the hepatitis B virus, and repeated rounds of necrosis and regeneration, also induced by hepatitis viruses. The genes involved and the mutations necessary for hepatic carcinogenesis are unknown, with the sole exception of the p53 gene, which is probably a late phenomenon. Screening for HCC is widely practiced despite the lack of evidence of improved survival. The screening tests used include alphafetoprotein levels and ultrasonography. Screening can identify small tumors; however, survival may not be improved, because the presence of cirrhosis may limit the number of patients who can undergo resections; recurr...Continue Reading

References

Dec 20, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·G Kendrey, B László
Jan 1, 1992·Journal of Gastroenterology and Hepatology·S ShimizuM Nakano
May 1, 1992·Journal of Hepatology·T LaskusJ Slusarczyk
Mar 1, 1992·Journal of Hepatology·B NalpasC Brechot
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C L MendenhallG A Roselle
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S NishiguchiS Yamamoto
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T PoynardJ C Chaput
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A ParésJ Rodés
Jul 1, 1989·Journal of Medical Virology·N HoriikeY Ohta
Dec 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C TiribelliK Ohnishi
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E WalterW Gerok
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J R WandsC Brechot
Jun 10, 1982·The New England Journal of Medicine·C BréchotP Berthelot
Jun 11, 1983·British Medical Journal·J B SaundersR Williams
Jul 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K IkedaM Kawanishi
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L ZignegoG La Villa
Jan 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P PaterliniC Bréchot

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Citations

Jun 26, 2001·Journal of Gastroenterology and Hepatology·S K SarinB C Das
Jun 2, 2012·ISRN Oncology·Sene Waly RaphaelChen Yuxiang

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