Hepatocellular ultrastructure after ischemia/reperfusion injury in human orthotopic liver transplantation

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Satish N NadigKenneth D Chavin

Abstract

The number of patients requiring organ transplants still outpaces the number of available transplantable organs. During the process of orthotopic liver transplantation (OLTx), donor organs undergo significant stress resulting from ischemia and reperfusion. Healthy organs respond to this stressful environment with compensatory mechanisms that ideally allow for complete recovery. However, "marginal" organs do not compensate as well. Hepatic steatosis typically renders an organ nontransplantable; a liver with 30% or more fat has a 25% chance of primary nonfunction (PNF) or graft failure after a technically sound operation. In this study, we report on the significant markers of cellular ultrastructural change in steatotic livers. These include glycogen content, mitochondrial swelling, and hepatocellular blebbing. The data disclosed here argue that further investigation of these factors in marginal organs subjected to I/R may better facilitate our understanding of PNF.

Citations

Feb 27, 2007·Journal of Surgical Education·Satish N NadigSeth J Karp
Apr 1, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Gero PuhlPeter Neuhaus
Apr 13, 2019·International Journal of Molecular Sciences·Mónica B Jiménez-CastroCarmen Peralta

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