Hepatocyte apoptosis and the expression of Bcl-2 and Bax in Yin-jaundice rats

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Jian-Jun ZhangChi-Zhi Zhang

Abstract

To investigate the effects of Yinchen Shufu Decoction on hepatocyte apoptosis and the expression of its apoptosis-regulating gene Bcl-2 and Bax in Yin-jaundice rats. Forty-eight rats were divided randomly into 4 groups: the normal control group, Yin-jaundice model group, Yang-jaundice model group, Yinchen Shufu Decoction treatment group. The TUNEL assay and the immunohistochemistry assay were used to detect the apoptosis of hepatocytes and the expression of Bcl-2 and Bax in hepatocytes respectively. The rate of apoptosis cells in Yin-jaundice model group was higher significantly than that in Yang-jaundice model group and normal control group (P<0.01), the expression of Bcl-2 in Yinchen Shufu Decoction treatment group was higher significantly than that in Yin-jaundice model group (P<0.01 or P<0.05), and the expression of Bax in it was lower significantly than that in Ying-jaundice model group (P<0.01 or P<0.05). Yinchen Shufu Decoction can prevent hepatocyte apoptosis perhaps by up-regulating the expression of Bcl-2 and down-regulating the expression of Bax. It is one of the mechanisms of its treatment on Yin-jaundice.

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Citations

Jan 18, 2006·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Qing-Ming LiQi-Hui Huang
Mar 15, 2006·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Li-Hong FanBin Cheng
Jan 1, 2010·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Jinyang LinYing Shan

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