PMID: 39544Apr 15, 1979

Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase

The Biochemical Journal
G C YeohI T Oliver


Liver of rat foetuses from 14 to 19 days of gestation and cultured hepatocytes derived from foetuses of 14 or 15 days gestation show a limited capacity to transaminate tyrosine. This low tyrosine transamination activity can be ascribed to aspartate aminotransferase. Definitive tyrosine aminotransferase can be demonstrated in 1-day-old cultures of hepatocytes taken from 19-day foetuses, but not from 15-day foetuses. However, after 3 days of culture hepatocytes from 15-day foetuses are able to synthesize tyrosine aminotransferase. Induction studies reveal that dexamethasone is capable of increasing tyrosine aminotransferase activity once it is detectable in culture.


Jul 1, 1981·European Journal of Cancer & Clinical Oncology·G C Yeoh
Dec 1, 1979·European Journal of Biochemistry·G S BulanyiI T Oliver
Jan 1, 1983·Differentiation; Research in Biological Diversity·R J Scott, G C Yeoh
Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E BakerP Ponka
Jan 1, 1983·Radiation and Environmental Biophysics·A M KuzinT E Ushakova
May 1, 1984·The Journal of Experimental Zoology·P K PriscottI T Oliver
Jun 1, 1983·Biochemical Genetics·J E Piletz, H R Herschman
Sep 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D TrinderE Baker
Jul 1, 1983·Cell Biochemistry and Function·R Biondi, M P Viola-Magni
Nov 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·W H LamersR Charles

Related Concepts

Cell Differentiation Process
Molecular Sieve Chromatography
Tyrosine Aminotransferase

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