Hepatocyte growth factor and cardiovascular thrombosis in patients admitted to the intensive care unit

Circulation Journal : Official Journal of the Japanese Circulation Society
Noritake HataKyoichi Mizuno

Abstract

Hepatocyte growth factor (HGF) has been reported as a marker of atherosclerosis and of thrombi synthesis, but the relationship between HGF and proven coronary thrombi has not been described. The aim of this study was to investigate this relationship in patients with chest pain. The study group comprised 107 patients with chest pain (61 acute myocardial infarction (AMI), 18 unstable angina, 15 stable angina, and 13 others; 65 males, 42 females; 66+/-11 years old). The presence of thrombi was evaluated by angiography, intravascular ultrasonography, angioscopy, and computed tomography. Serum HGF concentrations were measured using a new enzyme-linked immunosorbent assay. Serum HGF was significantly higher in the patients with AMI (335.0 +/-197.5 pg/ml), unstable angina (269.1+/-152.7 pg/ml), acute aortic dissection (320.3+/-116.5 pg/ml), and pulmonary thromboembolism (292.5+/-101.9 pg/ml), than in those with stable angina (171.2+/-56.1 pg/ml). Serum HGF concentration was also higher in those patients with proven thrombi than in those patients without (326.7+/-189.7 pg/ml vs 226.9+/-110.8 pg/ml). Increased serum HGF concentrations correlate with the presence of thrombi in patients with acute coronary syndrome, acute aortic dissectio...Continue Reading

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Citations

Oct 22, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·S KarabulutV Yasasever
Mar 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichi AkutsuTeruo Takano
May 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi HazuiToshiaki Hanafusa
Jun 27, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaki AwataSeiki Nagata
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Aug 30, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuhiro MaejimaMuneyasu Saito

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