Hepatocyte growth factor in glycerol-induced acute renal failure

Nephron
T GotoT Kishimoto

Abstract

Hepatocyte growth factor (HGF) facilitates the regeneration of injured kidney in acute renal failure (ARF). Here we investigated the HGF production in glycerol-induced ARF rats. HGF mRNA expression levels were elevated in liver, spleen, and lung 6-24 h after glycerol injection. Tissue HGF protein levels determined by an enzyme-linked immunosorbent assay also increased in liver and spleen, whereas they decreased in the injured kidney 24 h after injection. Immunohistochemical studies showed that the number of HGF-producing cells did not increase in the liver. HGF receptor/c-Met mRNA levels were elevated only in the kidney. These results indicate that HGF supplied in an endocrine manner may play an important role in the regenerating process following ARF.

Citations

Mar 20, 2001·Journal of Biomedical Materials Research·M A MooreM J Kowolik
Dec 28, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·A OkaM Yokoyama
May 31, 2001·Kidney International·K Matsumoto, T Nakamura
Aug 5, 2000·Current Opinion in Nephrology and Hypertension·K MatsumotoT Nakamura
Nov 16, 2007·International Archives of Allergy and Immunology·Wataru ItoArihiko Kanehiro
Mar 21, 2007·Biochemical Society Transactions·B Grzelakowska-SztabertM Manteuffel-Cymborowska
Feb 13, 2009·Clinical and Translational Science·Vishal S VaidyaJoseph V Bonventre
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C HaugE Rozdzinski
Apr 2, 2002·Biochemical and Biophysical Research Communications·Shunichi SuzukiHideaki Tojo

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