Hepatocyte growth factor-modified adipose tissue-derived stem cells improve erectile function in streptozotocin-induced diabetic rats

Growth Factors
T LiuWan Zhong

Abstract

TGFβ1-Smad signaling pathway is closely related to various tissues fibrosis. Hepatocyte growth factor (HGF) has been shown to antagonize TGFβ1-Smad signaling and may improve kidney tissue fibrosis in diabetic models. Penile fibrosis is a pathological condition which occurs during diabetic erectile dysfunction (ED). The aim of this study was to examine the effect of the treatment of ED in diabetic rats with a combination of HGF and adipose tissue-derived stem cells (ADSC). In this diabetes model, rats were injected intraperitoneally with 60 mg streptozotocin (STZ) to induce diabetes. Three months later, the diabetic rats were divided into a negative control(NC) group, an ADSC-treated group and an ADSC + HGF-treated group while normal rats were assigned into a sham group. Rats in the sham and NC groups were injected in the corpus cavernosum with phosphate-buffered saline, while rats in the other groups were injected with either ADSC or ADSC + HGF. One month later, erectile function was examined in each group and penile tissues were collected for experiments. The expression of smooth muscle actin (SMA) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) was analyzed by Western blotting. The smooth muscle and collagen depos...Continue Reading

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Citations

Jan 14, 2016·Current Opinion in Urology·M Ayodhia SoebadiMaarten Albersen
Aug 6, 2016·Arab Journal of Urology·Ezzat A Ismail, Ahmed I El-Sakka
Aug 22, 2016·Sexual Medicine Reviews·Fuat KizilayEge Can Serefoglu
Aug 15, 2018·Expert Opinion on Pharmacotherapy·Ahmed I El-Sakka
Oct 12, 2018·Expert Opinion on Biological Therapy·Serap GurWayne J G Hellstrom
Oct 28, 2018·Nature Reviews. Urology·Uros MilenkovicFabio Castiglione
Apr 19, 2017·International Urology and Nephrology·Quan-Liang HouWei-Dong Zhang
Sep 23, 2018·International Urology and Nephrology·Jiang-Lei ZhangJian-Quan Hou

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