Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells

Neuroreport
Feng LanLingsong Li

Abstract

Hepatocyte growth factor (HGF) and its receptor c-Met are widely expressed in the developing and adult brain. However, little is known about the role of HGF during the development of the human dopaminergic neuronal system. We have established telomerase-immortalized dopaminergic progenitor cells isolated from the fetal striatum that express markers for neural progenitor cells and tyrosine hydroxylase. We show that the cells were able to differentiate into dopaminergic neurons and release dopamine. Exogenous HGF-induced proliferation was inhibited by U0126, whereas migration was completely blocked by LY294002. Study demonstrates that HGF regulates the proliferation and migration of dopaminergic progenitor cells. Modulating dopaminergic progenitor cells in the striatum may prove to be a new approach for treating Parkinson's disease.

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Citations

Jun 6, 2013·Molecular and Cellular Biochemistry·Jin-Feng LiYun-Liang Wang
Dec 6, 2012·Parkinson's Disease·John W Wright, Joseph W Harding
Apr 27, 2012·Journal of Neuroscience Research·Catherine M SchwartzMark P Mattson
Jun 18, 2010·CNS Neuroscience & Therapeutics·Trevor Archer
Dec 3, 2014·Progress in Neurobiology·John W WrightJoseph W Harding
Jun 30, 2016·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Abigail P McCallumMartin E Weinand
Sep 5, 2014·The Journal of Pharmacology and Experimental Therapeutics·Caroline C BenoistJoseph W Harding
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Claudia DesoleTiziana Crepaldi

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