Hepatocyte growth factor secreted by ovarian cancer cells stimulates peritoneal implantation via the mesothelial-mesenchymal transition of the peritoneum

Gynecologic Oncology
Michihiko NakamuraMasahide Ohmichi

Abstract

A current working model for the metastatic process of ovarian carcinoma suggests that cancer cells are shed from the ovarian tumor into the peritoneal cavity and attach to the layer of mesothelial cells that line the inner surface of the peritoneum, and several studies suggest that hepatocyte growth factor (HGF) plays an important role in the dissemination of ovarian cancer. Our objectives were to evaluate the HGF expression of ovarian cancer using clinical data and assess the effect of HGF secreted from human ovarian cancer cells to human mesothelial cells. HGF expression was immunohistochemically evaluated in 165 epithelial ovarian cancer patients arranged as tissue microarrays. HGF expression in four ovarian cancer cell lines was evaluated by using semi-quantitative polymerase chain reaction, Western blotting and enzyme-linked immunosorbent assay. The effect of ovarian cancer cell derived HGF to the human mesothelial cells was assessed by using morphologic analysis, Western blotting and cell invasion assay. The effect of HGF on ovarian cancer metastasis was assessed by using in vivo experimental model. The clinical data showed a significantly high correlation between the HGF expression and the cancer stage. The in vivo and i...Continue Reading

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Citations

Mar 2, 2017·The Journal of Pathology·Angela Rynne-VidalManuel López-Cabrera
Mar 25, 2017·Experimental & Molecular Medicine·Ki-Hyun Kim, Hyori Kim
Mar 25, 2017·Experimental & Molecular Medicine·Hyori KimIn-Hoo Kim
Jul 3, 2016·Reproductive Sciences·Peter A W RogersUNKNOWN WES/WERF Consortium for Research Priorities in Endometriosis
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jian-Ming TangLi Hong
Oct 24, 2019·Cancers·Mohamed A Abd El AzizAnd Anirban K Mitra
May 4, 2016·Molecular Diagnosis & Therapy·Kim Moran-Jones
Nov 2, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zhi-Hong ZongYang Zhao
Jan 12, 2017·International Journal of Molecular Sciences·Agnieszka HoralaZenon J Kokot
Feb 1, 2017·Reproductive Sciences·A W PeterUNKNOWN WES/WERF Consortium for Research Priorities in Endometriosis
Mar 20, 2021·Molecular Oncology·Daniel Martin KlotzJan Dominik Kuhlmann
Jun 11, 2021·Frontiers in Oncology·Jing GaoLian Liu
Apr 20, 2020·Experimental and Molecular Pathology·Jesse DemuytereAnne Hoorens

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