Hepatocyte Growth Factor Suppresses Inflammation and Promotes Epithelium Repair in Corneal Injury

Molecular Therapy : the Journal of the American Society of Gene Therapy
Masahiro OmotoSunil K Chauhan

Abstract

Corneal injuries are among the major causes of ocular morbidity and vision impairment. Optimal epithelial wound healing is critical for the integrity and transparency of the cornea after injury. Hepatocyte growth factor (HGF) is a mitogen and motility factor that primarily regulates epithelial cell function. Herein, we investigate the effect of HGF on proliferation of corneal epithelial cells (CECs) in inflamed conditions both in vitro and in vivo. We demonstrate that HGF not only promotes CEC proliferation in homeostatic conditions but also reverses the anti-proliferative effect of the inflammatory environment on these cells. Furthermore, using a mouse model of ocular injury, we show that HGF treatment suppresses ocular inflammation and actively augments CEC proliferation, leading to improved and accelerated corneal epithelial repair. These findings have potential translational implications and could provide a framework for the development of novel HGF-based therapies for corneal epithelial defects.

References

Jan 31, 1991·Biochemical and Biophysical Research Communications·T IgawaT Nakamura
Jan 1, 1989·Eye·R A ThoftN Sundarraj
Nov 21, 1998·Archives of Ophthalmology·T P O'BrienC C Chan
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F GalimiP M Comoglio
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·G PellegriniM De Luca
Sep 1, 2001·Clinical and Experimental Immunology·Q JiangY Komada
May 27, 2003·Investigative Ophthalmology & Visual Science·Ilene K GipsonCindy Leigh Russo
Sep 29, 2004·Investigative Ophthalmology & Visual Science·Azucena KakazuHaydee E P Bazan
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katsuhide OkunishiKazuhiko Yamamoto
Sep 28, 2005·Investigative Ophthalmology & Visual Science·Mehrnoosh SaghizadehAlexander V Ljubimov
Oct 28, 2006·Experimental Eye Research·Audrey E K HutcheonJames D Zieske
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katsuhide OkunishiKazuhiko Yamamoto
Mar 4, 2008·Experimental Eye Research·Danielle M RobertsonH Dwight Cavanagh
May 27, 2008·The American Journal of Pathology·Myrto GiannopoulouYouhua Liu
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sunil K ChauhanReza Dana
Sep 8, 2009·Brain Research Bulletin·Fu-Shin X YuJenny Huang
Nov 26, 2009·Investigative Ophthalmology & Visual Science·Mehrnoosh SaghizadehAlexander V Ljubimov
Mar 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mahdia BenkhouchaPatrice H Lalive
May 9, 2012·Investigative Ophthalmology & Visual Science·Yinan LanSunil K Chauhan
Mar 14, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi KusunokiRyuichi Morishita
Oct 4, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Lee R Katzman, Bennie H Jeng
Dec 17, 2014·Science Translational Medicine·Sayan BasuJames L Funderburgh
Jul 22, 2015·Progress in Retinal and Eye Research·Alexander V Ljubimov, Mehrnoosh Saghizadeh
Oct 2, 2015·Scientific Reports·Maho NagataShigeru Kinoshita
Oct 4, 2016·Stem Cell Reports·Sharad K MittalSunil K Chauhan

❮ Previous
Next ❯

Citations

Jun 11, 2019·Stem Cells Translational Medicine·Sharad K MittalSunil K Chauhan
Apr 14, 2019·Expert Opinion on Biological Therapy·Olla Al-JaibajiChe J Connon
Dec 31, 2019·Stem Cells International·Hongyan TaoLiqiang Wang
Jun 28, 2019·Frontiers in Bioengineering and Biotechnology·Mohammadmahdi MobarakiMasoud Mozafari
Jul 10, 2019·Current Eye Research·Sachin ShuklaSayan Basu
Nov 12, 2020·Biomaterials Science·Zoe HancoxFarshid Sefat
Jun 27, 2019·The Ocular Surface·Luke ZhuDanielle M Robertson
Oct 7, 2020·The Ocular Surface·Raul E Ruiz-LozanoAlejandro Rodriguez-Garcia
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Clotilde JumelleReza Dana
May 23, 2020·Experimental Eye Research·Gary H F YamVishal Jhanji
Feb 27, 2021·Drug Delivery and Translational Research·Angela CerusoRosa Maria Hernandez
Feb 23, 2021·Experimental Eye Research·Xin WangWeiyun Shi
Jul 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thang L PhamHaydee E P Bazan
Aug 13, 2021·Translational Vision Science & Technology·Suneel GuptaRajiv R Mohan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.