Hepatocyte growth factor treatment improves alveolarization in a newborn murine model of bronchopulmonary dysplasia

Neonatology
Yasushi OhkiAkihiro Morikawa

Abstract

Bronchopulmonary dysplasia (BPD) is thought to be one form of developmental arrest of the lung. Hepatocyte growth factor (HGF) participates in normal lung growth and in lung regeneration. The purpose of this study is to investigate whether HGF can improve alveolarization and attenuates functional abnormalities of a murine model of BPD induced by hyperoxia. Three-day-old CD-1 mice were exposed to 90% of oxygen or room air (control group) for 7 days. These animals were then kept in room air for the next 7 days. Recombinant human (rh) HGF (100 microg/g b.w., divided 3 times, rhHGF group) or vehicle (vehicle group) was administered intraperitoneally during hyperoxia. On day 17, the pulmonary function test and bronchial hyperresponsiveness (BHR) were examined. Mean linear intercepts (MLI) were measured as parameters of alveolarization. Cell renewal (on day 10) and vascularization of the lung were also evaluated. Exposure to hyperoxia induced increased airway resistance and BHR. These animals showed a severely simplified alveolar structure, increased MLI, decreased cell renewal (16.1 +/- 2.4 vs. 29.6 +/- 2.4%, p < 0.05), and decreased vascularization (15.1 +/- 0.3 vs. 18.4 +/- 1.5 vessels/hpf, p < 0.05, vehicle vs. control group, res...Continue Reading

Citations

Mar 10, 2012·Antioxidants & Redox Signaling·Rajesh S AlphonseBernard Thébaud
Jan 18, 2011·American Journal of Respiratory Cell and Molecular Biology·Sharon A McGrath-MorrowShyam Biswal
Mar 29, 2014·American Journal of Respiratory Cell and Molecular Biology·Yun Sil ChangWon Soon Park
Dec 19, 2015·American Journal of Respiratory and Critical Care Medicine·Olivier BoucheratFrançois Maltais
Sep 7, 2014·Respiratory Research·Christina V JonesSharon D Ricardo
May 1, 2010·Seminars in Fetal & Neonatal Medicine·Vineet Bhandari
Mar 1, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Vineet Bhandari
Apr 3, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gregory SeedorfSteven H Abman
Jun 24, 2018·Nature Communications·Katsuhiro KatoRalf H Adams
Mar 24, 2009·Trends in Molecular Medicine·Jacques R BourbonChristophe Delacourt

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