Hepatocyte growth factor/scatter factor stimulates migration of muscle precursors in developing mouse tongue

Journal of Cellular Physiology
Kenjiro BandowYasushi Daikuhara

Abstract

Hepatocyte growth factor (HGF) stimulates the migration of myogenic cells during the development of skeletal muscles. The inactivation of HGF genes or that of its receptor, c-met, in mice causes hypoplasia of skeletal muscle organs, such as the tongue. Basic fibroblast growth factor (FGF-2) also induces migration of skeletal myoblasts. A comparison of the functions of HGF and FGF-2 in myogenesis revealed the crucial effect of HGF in the development of skeletal muscles. Unlike FGF-2, HGF induced migration of myoblasts from the developing mouse tongue. The differences between the activities of HGF and FGF-2 were determined by comparing their effects on the expression of matrix metalloproteinase-9 (MMP-9) in myoblasts, C2C12 cells, cultured in collagen-coated dishes. The results showed that HGF, but not FGF-2, stimulated MMP-9 expression, and that the stimulation was mediated through the activation of phosphoinositide 3-kinase (PI3K) which was not associated with FGF-2 signal transduction. Nevertheless, both growth factors exerted almost the same effect on the reduction of myogenin expression in, and on the proliferation of, C2C12 cells, suggesting that HGF, rather than FGF-2, plays a crucial role in the generation of skeletal mus...Continue Reading

References

Mar 15, 1991·Biochemical and Biophysical Research Communications·Y YoshiyamaH Tsubouchi
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K M WeidnerY Daikuhara
Mar 15, 1994·Biochemical and Biophysical Research Communications·M SasakiJ Enami
Oct 4, 1996·The Journal of Biological Chemistry·S E DunsmoreH G Welgus
Mar 21, 1998·Clinical & Experimental Metastasis·H LiM Tanaka
Jun 23, 1998·Current Biology : CB·H AmthorK Patel
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L TrusolinoP M Comoglio
Oct 28, 1998·Trends in Cell Biology·C Birchmeier, E Gherardi
Jan 25, 2000·American Journal of Physiology. Cell Physiology·K J MillerG K Pavlath
Feb 5, 2000·Developmental Biology·P Seale, M A Rudnicki
Jun 10, 2000·Molecular and Cellular Biology·J SuzukiH Koide
Jun 28, 2000·The Journal of Cell Biology·U SchaeperW Birchmeier
Jul 18, 2000·Experimental Cell Research·E El FahimeJ P Tremblay
Sep 20, 2000·The Journal of Cell Biology·M SachsW Birchmeier
Oct 6, 2000·Endocrine-related Cancer·C J PowersA Wellstein
Nov 7, 2000·Current Opinion in Cell Biology·C Birchmeier, H Brohmann
Mar 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y-H ParkC K Min
Jul 9, 2003·The Journal of Biological Chemistry·Josiane SancéauBrigitte Bauvois

❮ Previous
Next ❯

Citations

Oct 8, 2005·American Journal of Respiratory and Critical Care Medicine·Richard J SchwabAllan I Pack
Jan 26, 2012·Development·Susan M Abmayr, Grace K Pavlath
Oct 18, 2011·Experimental Cell Research·Min Jeong KimHye Sun Kim
Jul 27, 2005·Respiratory Physiology & Neurobiology·Richard J Schwab
Jan 17, 2009·The American Journal of Pathology·William WangYong Li
Oct 25, 2016·FEBS Letters·Mitsuhiro HisadomeTetsuya Matsuguchi
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nasser Al-ShantiClaire E Stewart
Sep 13, 2005·Current Opinion in Neurology·Janine Ehrhardt, Jennifer Morgan
Jan 11, 2007·Cancer Research·Daniel WilliamsonJanet Shipley
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Mohammadreza MohammadabadiWei Guo

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.