PMID: 7013255Jan 1, 1981Paper

Hepatocyte localization of hepatitis B core and surface antigens in renal transplant recipients. An ultrastructural prospective study

Virchows Archiv. A, Pathological Anatomy and Histology
D AmatJ Bedrossian

Abstract

A prospective series of 45 liver biopsies taken from 22 renal transplant patients was investigated for the presence of hepatitis B antigen core (HBc) and surface (HBs) components by electron microscopy. At the time of each biopsy serum HBs Ag was sought by radioimmunoassay. Sections were taken for the detection of HBs Ag by immunofluorescence. In seropositive patients, intravesicular tubular structures resembling HBs Ag were found in 61% of biopsies while the intranuclear core HBc was present in 69%. No correlation could be made between the ultrastructural pattern of the viral components and the intensity of the histological liver damage. During the follow up, there was an accumulation of both HBs and HBc Ag even in a period as short as 1 year. The 9 liver specimens examined after three years of transplantation showed a marked accumulation of both antigens. Thus the expression of HB Ag at the hepatocellular level seems to correlate better with the duration of antigenaemia than with the histological pattern. Lastly, on matched semithin and ultrathin sections, the ground glass appearance of cytoplasm appeared to correlate with smooth endoplasmic reticulum distorsion, irrespective of the simultaneous presence or absence of intrave...Continue Reading

References

Jan 1, 1978·The American Journal of Medicine·J Sopko, S Anuras
Jan 1, 1976·Gastroenterologia Japonica·K Shindo, K Fukushima
Apr 1, 1972·American Journal of Diseases of Children·O SteinY Stein
Mar 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·M A GerberH Popper

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Citations

Jan 1, 1988·Experimental Pathology·P ReinkeT Decker
Jun 15, 2011·Carcinogenesis·Teresa PollicinoGiovanni Raimondo
Jan 17, 2009·Cancer Letters·I Chemin, F Zoulim

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