Hepatocyte Nuclear Factor-1β Regulates Urinary Concentration and Response to Hypertonicity

Journal of the American Society of Nephrology : JASN
Karam AboudehenPeter Igarashi

Abstract

The transcription factor hepatocyte nuclear factor-1β (HNF-1β) is essential for normal kidney development and function. Inactivation of HNF-1β in mouse kidney tubules leads to early-onset cyst formation and postnatal lethality. Here, we used Pkhd1/Cre mice to delete HNF-1β specifically in renal collecting ducts (CDs). CD-specific HNF-1β mutant mice survived long term and developed slowly progressive cystic kidney disease, renal fibrosis, and hydronephrosis. Compared with wild-type littermates, HNF-1β mutant mice exhibited polyuria and polydipsia. Before the development of significant renal structural abnormalities, mutant mice exhibited low urine osmolality at baseline and after water restriction and administration of desmopressin. However, mutant and wild-type mice had similar plasma vasopressin and solute excretion levels. HNF-1β mutant kidneys showed increased expression of aquaporin-2 mRNA but mislocalized expression of aquaporin-2 protein in the cytoplasm of CD cells. Mutant kidneys also had decreased expression of the UT-A urea transporter and collectrin, which is involved in apical membrane vesicle trafficking. Treatment of HNF-1β mutant mIMCD3 cells with hypertonic NaCl inhibited the induction of osmoregulated genes, in...Continue Reading

References

Mar 1, 1987·The Journal of Clinical Investigation·D G BichetC Kortas
Apr 19, 1996·The Journal of Biological Chemistry·P IgarashiG T Nagami
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·H MiyakawaH M Kwon
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·N TakahashiO Smithies
Sep 21, 2000·The Journal of Biological Chemistry·Y NakayamaS M Bagnasco
Apr 12, 2001·BMC Developmental Biology·S SrinivasF Costantini
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Yun BaiPeter Igarashi
Oct 24, 2002·The Journal of Biological Chemistry·Yanqiao ZhangPeter A Edwards
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Cristina López-RodríguezEric N Olson
Mar 19, 2004·The EMBO Journal·Lionel GreshMarco Pontoglio
Apr 8, 2004·Annals of Internal Medicine·Christine Bellanné-ChantelotJosé Timsit
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Robert A FentonMark A Knepper
Oct 14, 2005·Kidney International·Peter IgarashiThomas Hiesberger
Nov 18, 2005·Biochemical and Biophysical Research Communications·Fuminori UmenishiRobert W Schrier
Dec 7, 2005·Cell Metabolism·Kenji FukuiKazuya Yamagata
Dec 13, 2005·Nature Genetics·Evelyne FischerMarco Pontoglio
Apr 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bradley W McDillFeng Chen
Sep 21, 2006·American Journal of Physiology. Renal Physiology·Sandra M MalakauskasThu H Le
Dec 15, 2006·Nature·Ursula DanilczykJosef M Penninger
Dec 28, 2006·American Journal of Physiology. Renal Physiology·Kenji MachidaHiroshi Nonoguchi
Feb 3, 2007·Journal of the American Society of Nephrology : JASN·Stéphane DecramerChristine Bellanné-Chantelot
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zhendong MaPeter Igarashi
Jan 4, 2008·American Journal of Physiology. Renal Physiology·Ryosuke MakitaHiroki Kurihara
Oct 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Miguel A LanaspaTomas Berl
Nov 14, 2008·Journal of the American Society of Nephrology : JASN·Yimei GongPeter Igarashi
Apr 25, 2009·Journal of the American Society of Nephrology : JASN·Shazia AdalatDetlef Bockenhauer
Dec 8, 2009·Nature Medicine·Francisco VerdeguerMarco Pontoglio
Apr 10, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Laurence HeidetRémi Salomon
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yun-Hee ChoiPeter Igarashi
Sep 15, 2012·Biomolecular Concepts·Chad BrockerVasilis Vasiliou
Jan 31, 2013·Development·Filippo MassaEvelyne Fischer
Jan 28, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyan ZhangYoufei Guan
Jun 6, 2014·American Journal of Physiology. Renal Physiology·Scott S WilliamsPeter Igarashi
Oct 31, 2014·Physiological Reports·Cameron R GradyJoan D Ferraris
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Jan 31, 2015·Nature Methods·Wolfgang HuberMartin Morgan
Jul 30, 2015·Physiological Genomics·Yuichiro IzumiJoan D Ferraris
Dec 15, 2015·The Journal of Biological Chemistry·Zhibo GaiGerd A Kullak-Ublick
Dec 30, 2015·Journal of the American Society of Nephrology : JASN·Karam AboudehenPeter Igarashi

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Citations

Aug 12, 2018·Journal of the American Society of Nephrology : JASN·Siu Chiu ChanPeter Igarashi
Jun 6, 2017·Nature Reviews. Nephrology·Andrea Aguilar
Sep 7, 2019·Nature Reviews. Disease Primers·Olivier DevuystAnthony J Bleyer
Jul 3, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Silvia Ferrè, Peter Igarashi
Jan 19, 2019·International Journal of Molecular Sciences·Jinzhao He, Baoxue Yang
Jul 18, 2018·International Journal of Molecular Sciences·Chang Yeob Han
Nov 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Siu Chiu ChanPeter Igarashi
Nov 27, 2020·Journal of the American Society of Nephrology : JASN·Christian HinzeKai M Schmidt-Ott
Mar 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lotte E TholenJeroen H F de Baaij
Apr 15, 2021·Cell Metabolism·Harini RamalingamVishal Patel
May 4, 2021·American Journal of Physiology. Renal Physiology·R B ThomsonP S Aronson
Aug 7, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Leah S HeidenreichChristian Hanna
Oct 16, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexis PiedrafitaStanislas Faguer
Nov 23, 2021·Frontiers in Physiology·Hyun Jun JungPaul A Welling

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