Hepatocyte nuclear factor 3beta participates in the transcriptional regulation of the thyroperoxidase promoter

Biochemical and Biophysical Research Communications
K Sato, R Di Lauro

Abstract

The promoters of the thyroglobulin (Tg) and thyroperoxidase (TPO) genes both contain sequences that match the consensus recognized by the fork-head family of transcription factors. The fork-head recognition element in the TPO promoter is recognized by two proteins, one of which is the transcription factor HNF-3beta, a member of the hepatocyte nuclear factor 3 (HNF-3) family, and the other is a thyroid-specific binding activity previously described as thyroid transcription factor 2 (TTF-2). Differently, only TTF-2 is capable of recognizing the fork-head recognition element in the thyroglobulin promoter, HNF-3beta protein is present in cultured thyroid cells and in the adult thyroid gland, suggesting that it does indeed have a role in modulating thyroid-specific gene expression. The transcriptional activities of TPO promoter mutants impaired in either TTF-2 or HNF-3beta binding suggest that both factors participate in regulating transcription from the TPO promoter.

Citations

Oct 7, 2004·Endocrine Reviews·Mario De Felice, Roberto Di Lauro
Mar 11, 2015·Scientific Reports·Gisella FiglioliAsta Försti
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R H CostaL Lim
Aug 29, 1998·Molecular and Cellular Endocrinology·C MisseroR Di Lauro

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