Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.

Gastroenterology
Wendy D GarrisonS A Duncan

Abstract

Hepatocyte nuclear factor 4 alpha (HNF4alpha) is a transcription factor that has been shown to be required for hepatocyte differentiation and development of the liver. It has also been implicated in regulating expression of genes that act in the epithelium of the lower gastrointestinal tract. This implied that HNF4alpha might be required for development of the gut. Mouse embryos were generated in which Hnf4a was ablated in the epithelial cells of the fetal colon by using Cre-loxP technology. Embryos were examined by using a combination of histology, immunohistochemistry, DNA microarray, reverse-transcription polymerase chain reaction, electrophoretic mobility shift assays, and chromatin immunoprecipitation analyses to define the consequences of loss of HNF4alpha on colon development. Embryos were recovered at E18.5 that lacked HNF4alpha in their colons. Although early stages of colonic development occurred, HNF4alpha-null colons failed to form normal crypts. In addition, goblet-cell maturation was perturbed and expression of an array of genes that encode proteins with diverse roles in colon function was disrupted. Several genes whose expression in the colon was dependent on HNF4alpha contained HNF4alpha-binding sites within put...Continue Reading

References

Nov 1, 1994·Mechanisms of Development·S TaravirasG Kelsey
Mar 6, 1997·Nature·K ChawengsaksophakF Beck
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·M Stoffel, S A Duncan
Mar 21, 1998·The Journal of Clinical Investigation·P MenetonG E Shull
Mar 17, 1999·Frontiers in Bioscience : a Journal and Virtual Library·S M Karam
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·X MaoS H Orkin
Dec 28, 1999·Annual Review of Cell and Developmental Biology·J M Wells, D A Melton
Dec 30, 1999·Nature Genetics·J JensenO D Madsen
Sep 26, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D J Roberts
Sep 14, 2001·The Journal of Biological Chemistry·N PerreaultK H Kaestner
Feb 22, 2002·Genesis : the Journal of Genetics and Development·Fereshteh ParvizStephen A Duncan
Mar 2, 2002·Science·Anna VelcichLeonard Augenlicht
Jun 18, 2002·Journal of Cellular and Molecular Medicine·J R Jass, M D Walsh
Sep 19, 2002·The Journal of Biological Chemistry·Alexandra Lerch-GagglStephen A Duncan
Jan 11, 2003·The Biochemical Journal·Lutz SchomburgJosef Köhrle
Jul 17, 2003·Genes & Development·Daniel PintoHans Clevers
Mar 16, 2004·Science·Anna-Pavlina G HaramisHans Clevers
Apr 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Helen H WangDavid Q-H Wang
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Elena SanchoHans Clevers
Feb 1, 2005·Developmental Biology·Catherine S LeeKlaus H Kaestner
Mar 26, 2005·Science·Elizabeth Pennisi
Mar 26, 2005·Science·Didier Y R Stainier
Mar 26, 2005·Science·Freddy Radtke, Hans Clevers
Mar 26, 2005·Science·Michael K Badman, Jeffrey S Flier

❮ Previous
Next ❯

Citations

Oct 11, 2011·Digestive Diseases and Sciences·Hao ChenXiaoxin Chen
Nov 17, 2009·Nature Genetics·UNKNOWN UK IBD Genetics ConsortiumDavid P Strachan
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Karthikeyani ChellappaFrances M Sladek
Jun 17, 2010·The Journal of Biological Chemistry·Mette BoydJesper T Troelsen
Oct 30, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chad WaleskyUdayan Apte
Jun 26, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wei ZhongZhanxiang Zhou
Apr 25, 2007·BMC Developmental Biology·Alistair J WattStephen A Duncan
Sep 19, 2009·BMC Gastroenterology·Mette BoydJesper T Troelsen
Feb 24, 2012·Journal of Lipid Research·Anna Algamas-DimantovBetty Schwartz
Jan 31, 2009·Molecular Endocrinology·Xuefen XieFrances M Sladek
Jan 1, 2008·Biological Chemistry·Karen GrigoGerhart U Ryffel
Feb 6, 2013·World Journal of Gastroenterology : WJG·Angélique Gougelet, Sabine Colnot
Jan 15, 2014·World Journal of Gastroenterology : WJG·Jean-Philippe Babeu, François Boudreau
Mar 27, 2015·Molecular Carcinogenesis·Hou Shan YaoWei Jun Wang
Nov 23, 2016·Differentiation; Research in Biological Diversity·Benjamin J ColleypriestDavid Tosh
Sep 13, 2014·Inflammatory Bowel Diseases·Declan F McCole
Sep 9, 2017·Inflammatory Bowel Diseases·Maaike VancamelbekeIsabelle Cleynen
Feb 15, 2011·Inflammatory Bowel Diseases·Alexandra I Thompson, Charlie W Lees
Jul 12, 2011·Inflammatory Bowel Diseases·Suzanne van SommerenRinse K Weersma
Jul 22, 2014·Nature·Bing ZhangUNKNOWN NCI CPTAC
Jun 25, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Benjamin D MooreJason C Mills
Jun 15, 2018·Journal of Cell Science·Jean-Philippe BabeuFrançois Boudreau
Aug 31, 2010·Journal of Cellular Biochemistry·Henrik R MaltesenJørgen Olsen
Feb 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kai SunStephen A Duncan
Aug 6, 2017·Gut·Victoria KlepschNatascha Hermann-Kleiter
Jul 9, 2008·Biochemistry. Biokhimii︠a︡·N L Lazarevich, D I Fleishman
Dec 3, 2008·International Journal of Cancer. Journal International Du Cancer·Betty SchwartzJacob Bar-Tana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.