Abstract
We describe the clinicopathologic findings in a so far unrecognized thymic tumor. The tumor occurred in a 70-year-old woman with respiratory distress but neither myasthenia gravis nor other symptoms. Metastases or another primary tumor were absent. The well-circumscribed neoplasm was located in the thymic region, measured 18 x 12 x 8 cm, and showed a homogeneous, tan-colored, soft cut surface. By histology, the tumor lacked a true capsule and a lobular growth pattern, was almost devoid of stroma, and infiltrated among remnant thymus lobules. The polygonal tumor cells formed solid sheets, trabeculae, or occurred as single cells that resembled hepatocytes. Proliferative activity was low. Portal structures, sinuses, and bile were absent as were areas of conventional thymoma, adenocarcinoma, or germ cell tumor. The tumor expressed cytokeratins 7 and 19, alpha1-antitrypsin, alpha1-antichymotrypsin, and hep-Par-1. Alpha-fetoprotein (AFP), human beta-chorionic gonadotropin (beta-HCG), placental alkaline phosphatase, CD5, CD30, CD31, CD34, CD45, CD68, CD99, S-100, HMB45, desmin, actin, or neuroendocrine markers were not expressed, and intratumorous CD1a+ or TdT+ immature T cells were absent. AFP was repeatedly undetectable in the blood...Continue Reading
References
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·H IshikuraK Mizuno
Jul 1, 1986·Cancer·H IshikuraM Aizawa
Dec 1, 1987·Cancer·H Ishikura, R E Scully
Dec 1, 1982·Cancer·J PratR E Scully
Dec 1, 1981·Cancer·A MasaokaT Tanioka
Apr 1, 1994·Cancer·J SinardJ Melamed
Sep 15, 1993·Cancer·E NagaiM Tsuneyoshi
Dec 1, 1993·The American Journal of Surgical Pathology·R H Young
Jan 1, 1995·The American Journal of Surgical Pathology·C Vardaman, J Albores-Saavedra
Jul 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Y HoshidaK Aozasa
Jul 1, 1997·Histopathology·H IshikuraT Yoshiki
Aug 1, 1997·The American Journal of Surgical Pathology·D M DorfmanJ K Chan
Sep 23, 1997·The American Journal of Surgical Pathology·L ArnouldT Petrella
Oct 23, 1997·The American Journal of Surgical Pathology·C A Moran, S Suster
Nov 14, 1997·The American Journal of Surgical Pathology·S SusterJ K Chan
Jul 7, 1998·The Journal of Experimental Medicine·L KleinB Kyewski
Nov 21, 1998·Histopathology·A S LeongC T Liew
Dec 31, 1998·Virchows Archiv : an International Journal of Pathology·M P FoschiniJ Rosai
May 7, 1999·Histopathology·M Devouassoux-ShisheboranF A Tavassoli
Jun 4, 1999·Pathology International·H SenzakiA Tsubura
Jun 12, 1999·The American Journal of Surgical Pathology·S Suster, C A Moran
Jun 12, 1999·The American Journal of Surgical Pathology·A Marx, H K Müller-Hermelink
Jun 26, 1999·Histopathology·S YonedaH K Müller-Hermelink
Aug 4, 1999·Virchows Archiv : an International Journal of Pathology·O BurguésA Llombart-Bosch
Aug 6, 1999·The American Journal of Surgical Pathology·S Suster, C A Moran
Sep 9, 1999·American Journal of Clinical Pathology·N L Harris, H K Müller-Hermelink
Sep 9, 1999·American Journal of Clinical Pathology·S Suster, C A Moran
Sep 14, 1999·Pathology, Research and Practice·C A Moran
Sep 14, 1999·Pathology, Research and Practice·R S Neiman, A Orazi
Mar 30, 2000·Cancer·G P PanerC V Reyes
May 3, 2000·Histopathology·H K Müller-Hermelink, A Marx
May 17, 2000·Diseases of the Colon and Rectum·C LattesW F Grigioni
Jul 6, 2000·The American Journal of Pathology·A ZettlA Marx
Jul 8, 2000·American Journal of Clinical Pathology·C A Moran, S Suster
Sep 7, 2000·Current Opinion in Oncology·H K Müller-Hermelink, A Marx
Sep 12, 2000·Journal of Hepato-biliary-pancreatic Surgery·H NakashimaH Kishikawa
Sep 30, 2000·Pathology International·Y Horie, M Kato
May 11, 2001·American Journal of Clinical Pathology·A MaitraJ Albores-Saavedra
Jul 18, 2001·Annals of Neurology·C BuckleyN Willcox
Aug 14, 2001·European Journal of Immunology·L KleinB Kyewski
Feb 22, 2002·Cancer·Meinoshin OkumuraAkira Masaoka
Jul 10, 2002·Trends in Immunology·Bruno KyewskiLudger Klein
Jul 19, 2002·Cancer·Gang ChenHans Konrad Mueller-Hermelink
Jul 23, 2002·Trends in Immunology·C Clare BlackburnMary A Ritter
Aug 10, 2002·The American Journal of Surgical Pathology·Peiguo G ChuLawrence M Weiss
Oct 12, 2002·Science·Mark S AndersonDiane Mathis
Dec 3, 2002·The American Journal of Surgical Pathology·Lara ChalabreysseFrançoise Thivolet-Bejui
Dec 28, 2002·The American Journal of Surgical Pathology·William W L ChoiJohn K C Chan
Jan 7, 2003·Human Pathology·Sean K LauRanda Alsabeh
Feb 20, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zhen FanRobert V Rouse
Citations
Sep 22, 2005·Surgery Today·Philipp StröbelHans Konrad Müller-Hermelink
Mar 16, 2005·The American Journal of Surgical Pathology·Daisuke NonakaJuan Rosai
Aug 2, 2007·The American Journal of Surgical Pathology·Luca Di TommasoJuan Rosai
Jun 26, 2012·Pathology International·Keita KaiOsamu Tokunaga
Jan 28, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Kristsanamon RittiluechaiClaire F Verschraegen
Jun 19, 2012·American Journal of Clinical Pathology·Annikka Weissferdt, Cesar A Moran
Aug 20, 2016·Der Pathologe·P StröbelA Marx
Aug 19, 2007·Diagnostic Cytopathology·Walid E KhalbussHarry J D'Agostino
Feb 26, 2016·Clinical Nuclear Medicine·Na HuYunhua Wang
Jun 5, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Annikka Weissferdt, Cesar A Moran
Jan 4, 2021·Virchows Archiv : an International Journal of Pathology·Anja C Roden, Malgorzata Szolkowska