Hepatokines as a Link between Obesity and Cardiovascular Diseases

Diabetes & Metabolism Journal
Hye Jin Yoo, Kyung Mook Choi

Abstract

Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the representative hepatokines fibroblast growth factor 21, fetuin-A, and selenoprotein P in the progression of CVD.

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Citations

Jan 20, 2016·International Journal of Molecular Sciences·Young Mi SongByung-Wan Lee
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