Hepatoprotective activities of Antrodia camphorata and its triterpenoid compounds against CCl4 -induced liver injury in mice

Journal of Ethnopharmacology
Zi-Wei LiMin Ye

Abstract

Antrodia camphorata (AC) is a rare and precious fungus indigenous to Taiwan used as a traditional medicine for the treatment of liver injury. Triterpenoids are the major bioactive constituents of A. camphorata and have been reported to possess hepatoprotective activities. To meet the increasing demand, artificial cultivation techniques have been developed. This study aims to evaluate the hepatoprotective activities of AC samples derived from different cultivation techniques and to dissect the main active triterpenoid compounds. The ethanol extracts of five batches of AC samples, including wild growing fruiting bodies, cutting wood culture fruiting bodies, dish cultures, cutting wood culture mycelia, and submerged fermentation mycelia were orally administered (50mg/kg or 200mg/kg) to ICR mice for 7 days. On the last day, CCl4 (0.2%, 7mL/kg, i.p.) was used to induce liver injury, and the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined 24h after the injection. Moreover, a HepG2 cell model treated with CCl4 (0.35%) was used to screen the protective activities of 29 AC triterpenoids. After incubation for 6h, viabilities of the cells were tested using MTS assay. The in vivo hepa...Continue Reading

Citations

Dec 31, 2019·Journal of Food and Drug Analysis·K J Senthil KumarSheng-Yang Wang
Feb 20, 2019·International Journal of Molecular Sciences·Tsu-Hsiang KuoShuang-En Chuang
Mar 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xu LixinYan Lijun
Aug 28, 2020·Journal of Asian Natural Products Research·Bin LiMin Ye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.