Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity

Journal of Ethnopharmacology
Jing TongYouwei Wang

Abstract

Cichorium glandulosum Boiss. et Huet was used historically in Uyghur folk medicine. Its roots, seeds, and aerial parts are extensively used by Uyghur residents in Xinjiang to eliminate savda typhoid, dredge and cure obstructive jaundice variety liver disorders. To evaluate the hepatoprotective activity of total flavonoids (TFs) obtained from C. glandulosum seeds against carbon tetrachloride (CCl4)-induced liver damage in vitro and in vivo. To investigate the mechanisms of hepatoprotective effects for TFs. The dried seeds of C. glandulosum were extracted with 70% aqueous ethanol, and the extract was chromatographed with D101 macroporous resin. In vitro the antioxidant capacity against lipid peroxidation (LPO) was evaluated using ferrothiocyanate, thiobarbituric acid, β-carotene bleaching, and LPO inhibition assay. The cytotoxicity and hepatoprotective activity of TFs were evaluated in human liver hepatoma cells (HepG2). MTT assay, hepatic injury markers aspartate aminotransferase (AST), alanine aminotransaminase (ALT), lactate dehydrogenase (LDH) leakage, malondialdehyde (MDA), and glutathione (GSH) were performed. In vivo the hepatoprotective activity of TFs against CCl4-induced acute liver injury was evaluated in rats. A serie...Continue Reading

References

Jan 1, 1988·Free Radical Biology & Medicine·S N Chatterjee, S Agarwal
Jan 1, 1997·Annual Review of Nutrition·M E Lowe
Apr 24, 2003·Critical Reviews in Toxicology·Lutz W D WeberAndreas Stampfl
Oct 17, 2007·FEMS Microbiology Letters·Jong Hoon KimChul Soo Shin
May 30, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H UpurA Talip
Sep 17, 2009·Journal of Cellular and Molecular Medicine·Jian-Ming LüChangyi Chen
Sep 17, 2009·Journal of Experimental Botany·Riklef Kandeler, Wolfram R Ullrich
Apr 27, 2010·Free Radical Biology & Medicine·Etsuo Niki
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E BorenfreundN Martin-Alguacil
May 17, 2011·Current Molecular Medicine·J González-GallegoS Sánchez-Campos
May 24, 2011·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Tao WuYuhua Sun
Jan 20, 2012·Free Radical Research·Alicja WinczuraBarbara Tudek
Mar 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Zoon TariqLeanne Hodson
Sep 4, 2014·Trends in Endocrinology and Metabolism : TEM·Claudia D FuchsMichael Trauner
Dec 17, 2014·Trends in Cell Biology·Morten Scheibye-KnudsenVilhelm A Bohr

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Citations

Apr 1, 2020·Indian Journal of Clinical Biochemistry : IJCB·Samir A E BashandyEnayat Abdel Aziz Omara
May 29, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ji MaJing Shang

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