Hepatoprotective Activity of Heptoplus on Isoniazid and Rifampicin Induced Liver Damage in Rats

Indian Journal of Pharmaceutical Sciences
Madhavan SankarDorai Sridhar

Abstract

The present study is designed to evaluate the efficacy of heptoplus a polyherbal formulation as an oral supplementary agent for isoniazid and rifampicin induced hepatotoxicity in rats. 50 and 100 mg/kg of heptoplus supplement were fed orally to the rats along with isoniazid and rifampicin and compared to rats treated with 100 mg/kg Liv 52 standard drug. Rats treated with isoniazid and rifampicin suffered from severe oxidative stress by the virtue of free radicals induced lipid per oxidation. As a result abnormal index of serum biochemical markers for liver function and increased liver lysosomal enzymes activity was observed. However rats nourished with 100 mg/kg of heptoplus and Liv 52 protected the liver from oxidative damage by maintaining normal antioxidant profile status and restored normal serum liver biochemical markers. Increased liver lysosomal enzymes activity is prevented in the rats supplemented with heptoplus and Liv 52. Histopathological analysis also revealed severe vascular changes and lobular necrosis in the treatment of isoniazid and rifampicin. Heptoplus (100 mg/kg) and Liv 52 supplemented rats liver apparently revealed normal architecture of liver. This study confirms that heptoplus has liver protective activ...Continue Reading

Citations

Jan 5, 2020·BMC Pharmacology & Toxicology·Orhan CimenEray Kurnaz
Oct 5, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Kavisa GhoshG Jagadeesan
Dec 14, 2016·Asian Pacific Journal of Tropical Medicine·María Adelina Jiménez-ArellanesRosalba León-Díaz
Mar 16, 2021·Heliyon·Priya BhatiaNidhi S Chandra

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