Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury in Ctenopharyngodon idellus

Oxidative Medicine and Cellular Longevity
Yajiao DuanShiyong Yang

Abstract

As an environmental and industrial pollutant, cadmium (Cd) can cause a broad spectrum of toxicological effects. Multiple organs, especially the liver, are considerably affected by Cd in both humans and animals. We investigated the protective effects of metallothionein (MT) and vitamin E (VE) supplementation on Cd-induced apoptosis in the grass carp (Ctenopharyngodon idellus) liver. Grass carp were divided into four groups: the control group, Cd + phosphate-buffered saline (PBS) group, Cd + VE group, and Cd + MT group. All fish were injected with CdCl2 on the first day and then VE, MT, and PBS were given 4 days postinjection, respectively. The results showed that Cd administration resulted in liver poisoning in grass carp, which was expressed as an increase in Cd contents, malondialdehyde (MDA) concentration, percentage of hepatocyte apoptosis, and apoptosis-related gene mRNA transcript expression. However, VE and MT treatments protected against Cd-induced hepatotoxicity in grass carp by decreasing Cd contents, lipid peroxidation, and histological damage and reducing the percentage of hepatocyte apoptosis by regulating related mRNA transcript expression. These data demonstrate that oxidative stress and activation of the caspase ...Continue Reading

References

Jun 21, 1985·Science·Y TsujimotoC M Croce
Feb 1, 1996·Biological Trace Element Research·S V Rana, S Verma
May 20, 1999·Annual Review of Pharmacology and Toxicology·C D KlaassenS Choudhuri
Jun 1, 2000·Journal of Inorganic Biochemistry·M P Waalkes
Jun 29, 2000·Annual Review of Biochemistry·W C EarnshawS H Kaufmann
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Nov 15, 2002·Journal of Cell Science·Céline CandéGuido Kroemer
May 27, 2003·Apoptosis : an International Journal on Programmed Cell Death·J D LyA Lawen
Dec 10, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Michiaki Yamashita
Oct 12, 2004·Toxicology Letters·Paula D B AdamisElis C A Eleutherio
Dec 9, 2004·Immunology Letters·Eric Eldering, René A W VanLier
Apr 27, 2005·Biological Trace Element Research·Zeynep ErdoganAli Unlu
May 14, 2005·CA: a Cancer Journal for Clinicians·Irene M GhobrialAlex A Adjei
Dec 21, 2005·Ecotoxicology and Environmental Safety·J C van DykJ H J van Vuren
Jun 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Muna AffaraCristin Print
Aug 25, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Alessia FormigariAlessandro Santon
Dec 13, 2007·Nature Reviews. Molecular Cell Biology·Rebecca C TaylorSeamus J Martin
Jun 24, 2008·Nature Reviews. Molecular Cell Biology·Yong-Ling P OwTak W Mak
May 3, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mohamed BanniImed Messaoudi
Sep 14, 2011·Toxicology and Industrial Health·Borhan MansouriHadi Babaei
Jun 5, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hai JinHou-Jin Huang
Jun 9, 2012·Toxicology and Applied Pharmacology·Kai C WuCurtis D Klaassen
Aug 27, 2013·Free Radical Biology & Medicine·Jhuli Keli AngeliDalton Valentim Vassallo
Apr 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wylly Ramsés García-Niño, José Pedraza-Chaverrí
Jan 17, 2015·Environmental Research·D G SfakianakisA M Tsatsakis
Sep 26, 2015·Inhalation Toxicology·Junfeng WangQingzhao Li

❮ Previous
Next ❯

Citations

Oct 18, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Paria AmanpourMasoud Salehipour
Apr 1, 2020·International Journal of Environmental Research and Public Health·Zhendong HeZhenghua Wang
Dec 14, 2018·Oxidative Medicine and Cellular Longevity·Camilo RiosAraceli Diaz-Ruiz
Aug 9, 2020·Environmental Science and Pollution Research International·Azza M A Abo-ElmaatyMohamed M Abdel-Daim
Dec 22, 2019·Environmental Science and Pollution Research International·Xianbin WangAhmed E Abdel Moneim

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
flow cytometry

Software Mentioned

Expo
SPSS

Related Concepts

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.