Hepatoprotective and Anti-Inflammatory Activities of the Cnidoscolus chayamansa (Mc Vaugh) Leaf Extract in Chronic Models

Evidence-based Complementary and Alternative Medicine : ECAM
Mariana Zuleima Pérez-GonzálezMaría Adelina Jiménez-Arellanes

Abstract

Previous report described that CHCl3:MeOH extract of C. chayamansa leaves and pure compounds (moretenol, moretenyl acetate, kaempferol-3,7-dimethyl ether, and 5-hydroxy-7-3',4'-trimethoxyflavanone) showed important topical and systemic anti-inflammatory activity in acute model, as well as in vitro antimycobacterial and antiprotozoal activities. In this paper, we describe the in vivo hepatoprotective and anti-inflammatory effects of the CHCl3:MeOH extract in chronic model and the isolation of additional compounds (moretenone and lupeol acetate). The hepatoprotective activity was determined at 39 days using Balb/c mice with liver damage induced with an antitubercular drug (RIF/INH/PZA). The anti-inflammatory activity was evaluated in a chronic model induced with CFA and in two acute models (TPA and carrageenan). In addition, moretenone and lupeol acetate were isolated and identified by spectroscopic data. Lupeol acetate is a main compound present in fractions 14-42, and this fraction was the majority fraction from the extract; from this moretenone was obtained. In animals with liver damage, the extract at 200 and 400 mg/kg induced better body weight gain with respect to positive control (Silymarin); in addition, the mice that rec...Continue Reading

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Feb 22, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mariana Z Pérez-GonzálezMaría A Jiménez-Arellanes

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Citations

Aug 21, 2021·Applied Microbiology and Biotechnology·Mariana Zuleima Pérez-González, María Adelina Jiménez-Arellanes

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Methods Mentioned

BETA
Nuclear Magnetic Resonance
X-ray

Software Mentioned

Bruker SAINT
SHELXS
SHELXL

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