Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease

BMC Complementary and Alternative Medicine
Jae-Chul JungYoung-Suk Jung

Abstract

Our previous study suggested that licorice has anti-inflammatory activity in lipopolysaccharide-stimulated microglial cells and anti-oxidative activity in tert-butyl hydroperoxide-induced oxidative liver damage. In this study, we evaluated the effect of licorice on chronic alcohol-induced fatty liver injury mediated by inflammation and oxidative stress. Raw licorice was extracted, and quantitative and qualitative analysis of its components was performed by using LC-MS/MS. Mice were fed a liquid alcohol diet with or without licorice for 4 weeks. We have standardized 70% fermented ethanol extracted licorice and confirmed by LC-MS/MS as glycyrrhizic acid (GA), 15.77 ± 0.34 μg/mg; liquiritin (LQ), 14.55 ± 0.42 μg/mg; and liquiritigenin (LG), 1.34 ± 0.02 μg/mg, respectively. Alcohol consumption increased serum alanine aminotransferase and aspartate aminotransferase activities and the levels of triglycerides and tumor necrosis factor (TNF)-α. Lipid accumulation in the liver was also markedly induced, whereas the glutathione level was reduced. All these alcohol-induced changes were effectively inhibited by licorice treatment. In particular, the hepatic glutathione level was restored and alcohol-induced TNF-α production was significant...Continue Reading

References

Jul 15, 1992·Biochemical and Biophysical Research Communications·I HardardóttirC Grünfeld
Jul 1, 1987·The Journal of Clinical Investigation·K R Feingold, C Grunfeld
Nov 1, 1994·Environmental Health Perspectives·G Cantelli-FortiM A Raggi
Feb 22, 2001·Free Radical Biology & Medicine·H KonoR G Thurman
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·H KonoR G Thurman
Jul 31, 2001·The Journal of Biological Chemistry·M D WheelerR G Thurman
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hye Gwang JeongHyo Kon Chun
Sep 18, 2002·Archives of Biochemistry and Biophysics·Stephen E McKimGavin E Arteel
Mar 4, 2003·Gastroenterology·Gavin E Arteel
Nov 11, 2011·International Journal of Molecular Sciences·Hai Zhong HuoYan Gu
Jan 7, 2014·Journal of Agricultural and Food Chemistry·Hong-Jhang ChenYun-Lian Lin
Jul 25, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji-Yeon YuSeikwan Oh

❮ Previous
Next ❯

Citations

Oct 9, 2016·Journal of Ethnopharmacology·Yuan-Yuan ZhanLi-Ping Tian
Jun 5, 2019·International Journal of Molecular Sciences·Ling-Zu KongTaeho Kwon
Oct 17, 2019·Foods·Mikkel R DeutchMarcus Krüger
Jul 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaowei HuoYanyan Zhao
Jul 19, 2019·Experimental and Therapeutic Medicine·Manaras KomolkriengkraiWipapan Khimmaktong
Nov 7, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shuang HuTao Xu
Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Małgorzata Kiełczykowska, Irena Musik
Nov 29, 2017·Journal of Agricultural and Food Chemistry·Yujia ZhaoChun Li
Jan 4, 2018·Integrative Medicine Research·Hwayong ParkJin Yeul Ma

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Young Suk JungYoung Chul Kim
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Changxing JiangQingping Xiong
© 2022 Meta ULC. All rights reserved