Hepatoprotective effect of Scoparia dulcis on carbon tetrachloride induced acute liver injury in mice

The American Journal of Chinese Medicine
Jen-Chieh TsaiChao-Ying Lee

Abstract

This study aims to investigate the hepatoprotective activity and active constituents of the ethanol extract of Scoparia dulcis (SDE). The hepatoprotective effect of SDE (0.1, 0.5 and 1 g/kg) was evaluated on the carbon tetrachloride (CCl(4))-induced acute liver injury. The active constituents were detected by high performance liquid chromatography (HPLC). Mice pretreated orally with SDE (0.5 and 1.0 g/kg) and silymarin (200 mg/kg) for five consecutive days before the administering of a single dose of 0.2% CCl(4) (10 ml/kg of bw, ip) showed a significant inhibition of the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Histological analyses also showed that SDE (0.5 and 1.0 g/kg) and silymarin reduced the extent of liver lesions induced by CCl(4), including vacuole formation, neutrophil infiltration and necrosis. Moreover, SDE decreased the malondialdehyde (MDA) level and elevated the content of reduced glutathione (GSH) in the liver as compared to those in the CCl(4) group. Furthermore, SDE (0.5 and 1.0 g/kg) enhanced the activities of anti-oxidative enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd) and glutathione-S-transferase (GST). ...Continue Reading

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Citations

Apr 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Isanete Geraldini Costa BieskiDomingos Tabajara de Oliveira Martins
Jul 23, 2016·Journal of Ethnopharmacology·Dong-Lin Li, Fu-Wu Xing
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Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Ika P DewiDiana Holidah

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