Hepatoprotective impact of the bile acid receptor TGR5.

Liver International : Official Journal of the International Association for the Study of the Liver
Grégory MerlenThierry Tordjmann

Abstract

During liver repair after injury, bile secretion has to be tightly modulated in order to preserve liver parenchyma from bile acid (BA)-induced injury. The mechanisms allowing the liver to maintain biliary homeostasis during repair after injury are not completely understood. Besides their historical role in lipid digestion, bile acids (BA) and their receptors constitute a signalling network with multiple impacts on liver repair, both stimulating regeneration and protecting the liver from BA overload. BA signal through nuclear (mainly Farnesoid X Receptor, FXR) and membrane (mainly G Protein-coupled BA Receptor 1, GPBAR-1 or TGR5) receptors to elicit a wide array of biological responses. While a great number of studies have been dedicated to the hepato-protective impact of FXR signalling, TGR5 is by far less explored in this context. Because the liver has to face massive and potentially harmful BA overload after partial ablation or destruction, BA-induced protective responses crucially contribute to spare liver repair capacities. Based on the available literature, the TGR5 BA receptor protects the remnant liver and maintains biliary homeostasis, mainly through the control of inflammation, biliary epithelial barrier permeability, ...Continue Reading

References

Mar 1, 1985·Steroids·S FukanoK Takeda
Aug 28, 1999·Gastroenterology·H MiyoshiG J Gores
Jul 21, 2000·Alimentary Pharmacology & Therapeutics·N CarulliP Loria
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B YerushalmiR J Sokol
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S SakisakaT Kurohiji
Jul 5, 2001·Gastroenterology·C SpirlìM Strazzabosco
Apr 12, 2002·Journal of Hepatology·Maria J MonteJose J G Marin
Nov 7, 2002·Biochemical and Biophysical Research Communications·Takaharu MaruyamaKenichi Tanaka
Jan 14, 2003·The Journal of Biological Chemistry·Yuji KawamataMasahiko Fujino
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Rebecca Taub
Jan 27, 2006·The American Journal of Pathology·Peter FickertMichael Trauner
May 27, 2006·The Biochemical Journal·Galya VassilevaEric L Gustafson
Oct 27, 2006·The Journal of Endocrinology·Takaharu MaruyamaYoshitaka Tamai
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Verena KeitelRalf Kubitz
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sergio A GradiloneNicholas F Larusso
Feb 2, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Francesco RaimondiRoberto Paludetto
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Young Joo ParkYoon Kwang Lee
May 13, 2008·Biochemical and Biophysical Research Communications·Verena KeitelDieter Häussinger
Aug 2, 2008·Nature Reviews. Drug Discovery·Charles ThomasKristina Schoonjans
Dec 18, 2008·European Journal of Clinical Investigation·P StärkelM J Monte
Jun 6, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Iván L CsanakyCurtis D Klaassen
Jul 8, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Verena KeitelDieter Häussinger
Sep 3, 2009·Cell Metabolism·Charles ThomasKristina Schoonjans
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·James M Anderson, Christina M Van Itallie
Mar 10, 2010·Molecular Endocrinology·Zhipeng MengWendong Huang
May 4, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Lucas Maillette de Buy Wenniger, Ulrich Beuers
Dec 15, 2010·Journal of Hepatology·Thijs W H PolsKristina Schoonjans
Apr 2, 2011·Molecular Endocrinology·Tingting LiDavid J Mangelsdorf
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simon HohenesterUlrich Beuers
Oct 19, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna BaghdasaryanMichael Trauner
Oct 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brigitte GrosseEmmanuel Gonzales
Dec 14, 2011·Cell Metabolism·Thijs W H PolsKristina Schoonjans

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Citations

Jul 28, 2020·Nutrients·Marlena M HolterBethany P Cummings
Jan 26, 2021·Médecine sciences : M/S·N'Diaye SidibéThierry Tordjmann
Mar 6, 2021·JHEP Reports : Innovation in Hepatology·Madeleine SpatzAnne-Marie Cassard
Mar 28, 2021·Scandinavian Journal of Gastroenterology·Ke MaLijin Zhao
Aug 18, 2021·Journal of Cardiovascular Translational Research·Jiaxing WangMing Xu

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