Hepatoprotective Properties of a Polyphenol-Enriched Fraction from Annona crassiflora Mart. Fruit Peel against Diabetes-Induced Oxidative and Nitrosative Stress

Journal of Agricultural and Food Chemistry
Allisson Benatti JustinoFoued Salmen Espindola

Abstract

A polyphenol-enriched fraction from Annona crassiflora fruit peel (Ac-Pef) containing chlorogenic acid, (epi)catechin, procyanidin B2, and caffeoyl-glucoside was investigated against hepatic oxidative and nitrosative stress in streptozotocin-induced diabetic rats. Serum biochemical parameters, hepatic oxidative and nitrosative status, glutathione defense system analysis, and in silico assessment of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the main compounds of Ac-Pef were carried out. Ac-Pef treatment during 30 days decreased serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities, as well as hepatic lipid peroxidation, protein carbonylation and nitration, inducible nitric oxide synthase level, and activities and expressions of glutathione peroxidase, superoxide dismutase, and catalase. There were increases in antioxidant capacity, glutathione reductase activity, and reduced glutathione level. ADMET predictions of Ac-Pef compounds showed favorable absorption and distribution, with no hepatotoxicity. A. crassiflora fruit peel showed hepatoprotective properties, indicating a promising natural source of bioactive molecules for prevention and therapy of diabete...Continue Reading

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Citations

Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Adriele V SouzaFoued S Espindola
Aug 23, 2020·Pharmaceutics·Lígia Nunes de Morais RibeiroBelchiolina Beatriz Fonseca
Feb 1, 2020·Journal of Clinical Biochemistry and Nutrition·Ana Luiza AmaralGuilherme M Puga
May 30, 2020·Food Research International·Lívia Garcia PradoGlaucia Maria Pastore
Sep 12, 2018·Ultrasonics Sonochemistry·Henrique S ArrudaGlaucia M Pastore

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