Hepatoprotective sesquiterpene glycosides from Sarcandra glabra

Journal of Natural Products
Yuan LiYong-Ming Luo

Abstract

Six new sesquiterpene glycosides, compounds 1-6, with eudesmanolide, elemanolide, lindenane, and germacranolide sesquiterpene aglycons, along with one known compound, chloranoside A (7), have been isolated from the whole plant of Sarcandra glabra. The structures of 1-6 were elucidated by chemical and spectroscopic methods including (1)H-(1)H COSY, HMQC, HMBC, and NOESY NMR experiments. In addition, compounds 1-7 showed pronounced hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.

References

Mar 30, 2001·Journal of Natural Products·I KounoT Tanaka

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Citations

Apr 24, 2009·Archives of Pharmacal Research·Hai-Xue KuangShao-Wa Lü
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Aug 27, 2011·Journal of Natural Products·Wenbing DingXiaoyi Wei
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