Hepatorenal syndrome in the era of acute kidney injury

Liver International : Official Journal of the International Association for the Study of the Liver
Cristina SoléP Ginès

Abstract

Acute kidney injury (AKI) is a frequent complication of patients with advanced cirrhosis that it is associated with increased hospital admissions and decreased survival. The definition of AKI in cirrhosis has been recently modified and the new diagnostic criteria are based on small changes in serum creatinine with respect to previous values, occurring within a short period of time. The use of this new definition may lead to an earlier identification of renal impairment and better prognostic stratification. Hepatorenal syndrome (HRS) is a unique form of AKI developing in patients with end-stage liver disease. Systemic circulatory dysfunction and marked kidney vasoconstriction play a key role in the development of HRS. The modification of the definition of AKI has also led to a change in the diagnostic criteria of HRS. The new diagnostic criteria are based on AKI stages and there is no need to reach a specific serum creatinine threshold. According to these new criteria, treatment with vasoconstrictors and albumin for the management of HRS will be started at lower serum creatinine values, with expected higher response rates. Finally, there are consistent data showing that some urine biomarkers, particularly NGAL (neutrophil gelati...Continue Reading

References

Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R W SchrierJ Rodés
Jan 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ArroyoJ Schölmerich
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NavasaJ Rodés
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M GuevaraJ Rodés
Aug 26, 1998·The New England Journal of Medicine·P Y MartinR W Schrier
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AngeliA Gatta
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rolando OrtegaJuan Rodés
Jan 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Deb S ShermanIsaac Teitelbaum
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florence WongKenneth Sniderman
Oct 16, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·José A Girón-GonzálezLeopoldo Martín-Herrera
Jun 25, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luis Ruiz-del-ArbolVicente Arroyo
Jun 28, 2005·Blood Purification·Kinan RifaiDanilo Fliser
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard Moreau, Didier Lebrec
Nov 1, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominique ThabutRichard Moreau
May 13, 2008·Gastroenterology·Marta Martín-LlahíUNKNOWN TAHRS Investigators
May 13, 2008·Gastroenterology·Arun J SanyalUNKNOWN Terlipressin Study Group
Nov 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoAntonella Viola
Sep 25, 2009·The New England Journal of Medicine·Pere Ginès, Robert W Schrier
Oct 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·André NazarPere Ginès
Nov 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lise L GluudAleksander Krag
Jul 17, 2010·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Aug 5, 2010·Gastroenterology·Marta Martín-LlahíPere Ginès
Mar 29, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Justin M BelcherUNKNOWN TRIBE-AKI Consortium
Apr 7, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cláudia Fagundes, Pere Ginès
Apr 17, 2012·Journal of Hepatology·Juan-Carlos García-PagánJaume Bosch
May 9, 2012·Digestive Diseases and Sciences·Elizabeth C VernaThomas L Nickolas
May 29, 2012·Gut·Cynthia D TsienFlorence Wong
Jul 25, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M K NadimY S Genyk
Mar 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Jay L Koyner, Chirag R Parikh
Sep 3, 2013·Journal of Hepatology·Reiner WiestMarkus Geuking
Sep 4, 2013·Gastroenterology·Florence WongUNKNOWN North American Consortium for Study of End-Stage Liver Disease
Jan 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Justin M BelcherUNKNOWN TRIBE-AKI Consortium
Jan 23, 2014·Journal of Hepatology·Ezequiel RodríguezPere Ginès
Sep 10, 2014·PloS One·Antonio Paulo Nassar JuniorLuiz Marcelo Sá Malbouisson
Apr 23, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Silvia RosiPaolo Angeli

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Citations

Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Shuet Fong NeongFlorence Wong
Sep 10, 2019·European Journal of Gastroenterology & Hepatology·George N KalambokisHaralampos J Milionis
Jul 11, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Christian M Lange
Jan 4, 2021·Digestive Diseases and Sciences·Caroline BaldinGustavo Pereira
Aug 28, 2020·Annals of Hepatology·Alicia S Ojeda-YurenSalvatore Piano
Mar 31, 2021·Kidney International·Garabed Eknoyan, Murray Epstein
Feb 6, 2021·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Irtiza HasanHani M Wadei
Jun 16, 2021·Seminars in Liver Disease·Kathy M Nilles, Josh Levitsky
Sep 28, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Cristina SoléPere Ginès
Oct 20, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pooja Basthi MohanShiran Shetty

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