Hepatorenal syndrome

The International Journal of Biochemistry & Cell Biology
Mónica Guevara, Juan Rodés

Abstract

Hepatorenal syndrome (HRS) is a major complication of patients with cirrhosis, with the annual incidence in patients with ascites being approximately 8% []. This syndrome develops in the latest phase of the disease and there is now evidence that it is an important determinant of patient survival. Many aspects of HRS are, however, still poorly understood. There are two types of HRS: type 1 or progressive HRS which is associated with a very poor prognosis (median survival rate lower than 2 weeks), and type 2 HRS which is characterized by a steady impairment in circulatory and renal function. The pathogenesis of HRS is a deterioration in effective arterial blood volume due to splanchnic arterial vasodilation and a reduction in venous return and cardiac output. It is therefore not surprising that the syndrome can be reversed by the simultaneous intravenous administration of albumin and arterial vasoconstrictors. Intrarenal mechanisms are also important and require prolonged improvement in circulatory function to be deactivated. Long-term administration of intravenous albumin and vasoconstrictors or the correction of portal hypertension with a transjugular intrahepatic portacaval shunt are effective in the treatment of HRS. They als...Continue Reading

References

Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R W SchrierJ Rodés
Jan 1, 1997·Seminars in Liver Disease·R BatallerV Arroyo
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M GuevaraJ Rodés
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AngeliA Gatta
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe DuvouxDaniel Dhumeaux
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rolando OrtegaJuan Rodés
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard Moreau, Didier Lebrec

❮ Previous
Next ❯

Citations

Dec 24, 2005·Der Anaesthesist·I KürerW Boemke
Feb 13, 2008·Cardiovascular and Interventional Radiology·Teik Choon SeeJonathan Tibballs
Nov 30, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Waheed Abdelmonsef MahmoudAmal Mansor
May 5, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alain Meyrier
Jul 16, 2014·Clinics in Liver Disease·Marcelo S SampaioSuphamai Bunnapradist
Oct 17, 2007·Digestive Diseases and Sciences·Sergio NeriPietro Castellino
May 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C L DavisJ Lake
Jan 8, 2008·Alimentary Pharmacology & Therapeutics·J J KuiperH R van Buuren
Mar 29, 2019·Oxidative Medicine and Cellular Longevity·Olivia Vázquez-MartínezMauricio Díaz-Muñoz
Jun 21, 2006·Scandinavian Journal of Gastroenterology·Duygu IbrisimAtilla Okten

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
N Kumar, D Grant
Psychotherapy and Psychosomatics
Hans-Bernd RothenhäuslerAlexander L Gerbes
© 2021 Meta ULC. All rights reserved