Hepatosplanchnic circulation in cirrhosis and sepsis

World Journal of Gastroenterology : WJG
Meghan PrinGebhard Wagener

Abstract

Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis. Liver cirrhosis is estimated to affect up to 1% of populations worldwide, including 1.5% to 3.3% of intensive care unit patients. Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage. Sepsis and cirrhosis result in similar circulatory changes and resultant multi-organ dysfunction. This review provides an overview of the hepatosplanchnic circulation in the healthy state and in cirrhosis, examines the signaling pathways that may play a role in the physiology of cirrhosis, discusses the physiology common to cirrhosis and sepsis, and reviews important issues in management.

References

Oct 16, 1975·Pflügers Archiv : European journal of physiology·J LutzE Bauereisen
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y LeeR J Groszmann
Sep 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S S LeeD Lebrec
Mar 1, 1985·The American Journal of Physiology·W W LauttM S d'Almeida
Sep 1, 1989·Canadian Journal of Physiology and Pharmacology·W W Lautt, J E McQuaker
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L TitóJ Rodés
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Jan 1, 1971·Physiological Reviews·C V Greenway, R D Stark
Oct 1, 1980·The American Journal of Physiology·W W Lautt
Jan 1, 1981·The American Journal of Physiology·T D Bennett, C F Rothe
Jul 1, 1994·Intensive Care Medicine·A R EdouardK Samii
Mar 1, 1994·Journal of Hepatology·R PicchiottiL Feroci
Jul 1, 1996·British Journal of Anaesthesia·J Takala
Aug 1, 1997·Digestive Diseases and Sciences·I CireraJ Rodés
Feb 19, 1999·Lancet·J GoulisA K Burroughs
Apr 13, 1999·The American Journal of Physiology·R WiestR J Groszmann
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PardoM A Gassull
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MalinchocP C ter Borg
Jun 2, 2000·Critical Care Medicine·S P Ponce de León-RosalesV G Vázquez-Ramos
Nov 30, 2000·American Journal of Physiology. Renal Physiology·L XuR W Schrier
Feb 24, 2001·Journal of Hepatology·I CireraJ Rodés
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A HelmyD J Webb
Apr 6, 2001·International Journal of Clinical & Laboratory Research·C M BrunoL Caruso
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S M JakobJ Takala
Apr 17, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M BorzioA Sangiovanni
Jun 26, 2001·The Journal of Surgical Research·A KhannaM G Caty

❮ Previous
Next ❯

Citations

Oct 19, 2016·Critical Care : the Official Journal of the Critical Care Forum·Petrus R de JongNicolaas J G Jansen
Feb 28, 2017·Journal of Magnetic Resonance Imaging : JMRI·Denise SchaffnerWilfried Reichardt
Dec 14, 2016·AACN Advanced Critical Care·Diane McLaughlin, Lori Shellenback
Apr 2, 2019·Mediators of Inflammation·Benjamin Wilde, Antonios Katsounas
May 23, 2019·Frontiers in Immunology·Felix HaussnerMarkus Huber-Lang
Jun 15, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Christoph SchneiderThorsten Kaiser
Nov 18, 2015·World Journal of Gastroenterology : WJG·Sara Blasco-AlgoraConrado M Fernández-Rodríguez
Jun 10, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dusan Hanidziar, Simon C Robson
Aug 13, 2020·Reviews on Recent Clinical Trials·Yaroslava LonghitanoFrancesco Franceschi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Der Internist
B E Strauer, H P Schuster
Bollettino della Società italiana di cardiologia
C MontemartiniM Giannattasio
Critical Care : the Official Journal of the Critical Care Forum
James M O'BrienEdward Abraham
© 2022 Meta ULC. All rights reserved