Hepatosplenic gamma delta T-cell lymphoma in a boy with visceral leishmaniasis: a case report

Journal of Medical Case Reports
Deepti MutrejaHara Prasad Pati

Abstract

Hepatosplenic gamma delta T-cell lymphoma is a rare peripheral T-cell lymphoma of cytotoxic T-cell origin with an aggressive clinical course. Chronic immunosuppression has been proposed as a possible pathogenetic mechanism. No association of hepatosplenic gamma delta T-cell lymphoma with visceral leishmaniasis has been described in the past. We describe a case of an adolescent boy with hepatosplenic gamma delta T-cell lymphoma with leukemic presentation, who was diagnosed to have visceral leishmaniasis, 9 months prior to presentation at our center. To the best of our knowledge this is the first report of hepatosplenic gamma delta T-cell lymphoma with a prior history of visceral leishmaniasis in the medical literature. A 13-year-old Indian boy presented to the hematology out-patient department with a history of progressive abdominal distension of 9 months' duration and low grade fever of 2 months' duration. He was a known case of visceral leishmaniasis and was treated with some clinical improvement in the past. However, his symptoms recurred and he was diagnosed to have hepatosplenic gamma delta T-cell lymphoma at our center. Cytogenetic analysis showed characteristic karyotype of isochromosome 7. Chronic antigen stimulation due...Continue Reading

References

Jul 24, 2003·Seminars in Hematology·Philippe GaulardFelix Reyes
Sep 3, 2008·Veterinary Clinical Pathology·Valentina Foglia ManzilloGaetano Oliva
Feb 25, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G S FalchookB Pro
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mariana DominguesMauricio Ostronoff

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BETA
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