Abstract
Hepatosplenic T-cell lymphoma is a rare, aggressive T-cell lymphoma, characterized by hepatosplenic sinusoidal infiltration of monotonous, medium-sized, nonactivated cytotoxic T cells, usually of γ/δ T-cell receptor type. Hepatosplenic T-cell lymphoma occurs more frequently in immunocompromised patients, especially in those receiving long-term immunosuppressive therapy. Patients usually manifest hepatosplenomegaly without lymphadenopathy. The bone marrow is also involved in two-thirds of cases and is often accompanied by circulating lymphoma cells, which, along with anemia and thrombocytopenia, may raise suspicion for acute leukemia. The differential diagnosis includes aggressive natural killer-cell leukemia, T-large granular lymphocytic leukemia, T-lymphoblastic leukemia, enteropathy-associated T-cell lymphoma type II, primary cutaneous γ/δ T-cell lymphoma, other peripheral T-cell lymphomas, myelodysplastic syndrome, and infectious mononucleosis. The diagnosis is usually established from the combination of clinical findings, histologic features, and immunophenotype, although cytogenetic/molecular studies are occasionally needed. Hepatosplenic T-cell lymphoma exhibits a dismal clinical course with a poor response to currently a...Continue Reading
References
Sep 1, 1992·Annals of Hematology·M WilhelmK Wilms
Jan 1, 1993·Annual Review of Immunology·W HaasS Tonegawa
Sep 1, 1996·Clinical Immunology and Immunopathology·M E RothenbergD A Hafler
Jun 1, 1997·Human Pathology·K E SalhanyM Kamoun
Dec 16, 1998·Journal of Gastroenterology·M YoshikawaH Nakamine
Jan 12, 1999·American Journal of Hematology·A NosariE Morra
Jun 24, 2000·Leukemia·E Weidmann
Jul 15, 2000·The American Journal of Surgical Pathology·F SuarezP Gaulard
Feb 27, 2001·The American Journal of Surgical Pathology·W R MaconJ B Cousar
Mar 29, 2001·The Journal of Molecular Diagnostics : JMD·G K PrzybylskiK E Salhany
Sep 14, 2001·American Journal of Clinical Pathology·F VegaL V Abruzzo
Jan 25, 2002·Genes, Chromosomes & Cancer·Iwona WlodarskaPhilippe Gaulard
Aug 9, 2003·Blood·Karim BelhadjPhilippe Gaulard
Sep 17, 2004·Leukemia & Lymphoma·Asher Chanan-KhanPhilip McCarthy
Jan 18, 2006·Journal of Cutaneous Pathology·Rein Willemze, Chris J L M Meijer
Feb 25, 2006·Blood·Claudine S BonderPaul Kubes
Jun 2, 2006·Cancer Genetics and Cytogenetics·Shashirekha ShettyBirgitte Roland
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip L SimonianAndrew P Fontenot
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie VoseUNKNOWN International T-Cell Lymphoma Project
Aug 7, 2008·Pediatric Blood & Cancer·Martine van GrotelJules P P Meijerink
Feb 25, 2009·British Journal of Haematology·Liuyan JiangMaryalice Stetler-Stevenson
May 2, 2009·Annals of Surgical Oncology·Andrew A GumbsOwen A O'Connor
Nov 11, 2009·Nature Reviews. Clinical Oncology·Claudio TripodoStefano Aldo Pileri
Jan 5, 2011·Pathology Oncology Research : POR·Murat AlbayrakAynur Albayrak
Sep 24, 2011·European Journal of Gastroenterology & Hepatology·Deepak ParakkalEli Daniel Ehrenpreis
Feb 18, 2012·American Journal of Clinical Pathology·Yi-Hua Chen, LoAnn Peterson
Jan 4, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lawrence M Weiss, Dennis O'Malley
Jun 27, 2013·Clinical Lymphoma, Myeloma & Leukemia·Ohad BenjaminiMichael J Keating
Sep 3, 2013·Archives of Pathology & Laboratory Medicine·David P Arps, Lauren B Smith
Citations
Oct 28, 2016·Virchows Archiv : an International Journal of Pathology·Arti KarpateLaurence de Leval
Mar 30, 2017·Leukemia & Lymphoma·Shuo-Chieh WuJuan Pablo Alderuccio
May 17, 2018·Clinical Journal of Gastroenterology·Marianna MaviliaHaleh Vaziri
Oct 4, 2018·Archives of Pathology & Laboratory Medicine·Shula Schechter, Laura Lamps
Feb 8, 2019·Cytometry. Part B, Clinical Cytometry·Dragan Jevremovic, Horatiu Olteanu
Mar 20, 2020·Cells·Sónia FonsecaMargarida Lima
Jul 28, 2019·Case Reports in Hematology·Laura AlderVictor Yazbeck
Aug 9, 2020·The Journal of International Medical Research·Xue ShiZhihe Liu
Feb 6, 2020·Current Hematologic Malignancy Reports·Lauren Shea, Neha Mehta-Shah
Apr 21, 2018·Indian Journal of Pathology & Microbiology·Richa ChauhanRenu Saxena
Nov 6, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Steven M HorwitzHema Sundar
Dec 28, 2019·Seminars in Diagnostic Pathology·Nadine S Aguilera, Aaron Auerbach
Nov 18, 2020·Seminars in Diagnostic Pathology·Osvaldo PadillaJulia T Geyer
Oct 4, 2020·Human Pathology·Philippa LiXiaoyan Liao
Apr 19, 2021·The Journal of Dermatology·Jun AkomeManabu Fujimoto
Jun 10, 2020·Cold Spring Harbor Perspectives in Medicine·José R Cortés, Teresa Palomero
Jun 8, 2021·Curēus·Madeleine E TurcotteNam H Dang