Hepatosplenomegaly and reticulocytopenia as prominent features of atypical hemolytic uremic syndrome

Pediatric Emergency Care
Kirsten Bechtel, Sandra Iragorri

Abstract

This is a case of atypical hemolytic uremic syndrome (HUS) due to invasive pneumococcal disease in which the prominent clinical features were reticulocytopenia and hepatosplenomegaly, leading to the incorrect initial diagnosis of acute leukemia. Delayed diagnosis of HUS, especially in atypical cases, can lead to increased morbidity and mortality. Atypical HUS must be part of the differential diagnosis of children who present with clinical characteristics suggestive of a hematologic malignancy with associated renal injury.

References

Jun 1, 1974·Archives of Disease in Childhood·P M van WieringenE D Schretlen
Apr 1, 1993·The Journal of Pediatrics·M M FitzpatrickT M Barratt
Dec 1, 1995·Pediatric Clinics of North America·R L Siegler
Aug 9, 2002·Journal of Gastroenterology and Hepatology·Takeshi MinamiShyuji Kanayama
May 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alex R ConstantinescuHoward Trachtman
Jun 8, 2006·Nephrology·Iradj Amirlak, Bardia Amirlak

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Citations

Mar 14, 2013·Current Opinion in Pediatrics·Joann M SpinaleLawrence Copelovitch
Mar 21, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ulkem Kocoglu BarlasEsra Sevketoglu

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