Hepatotoxicity of antiretroviral drugs in HIV HCV patients with congenital coagulopathies followed at an Haemophilia Unit during a decade

Haemophilia : the Official Journal of the World Federation of Hemophilia
S SauledaV Vargas

Abstract

The aim of the study was to assess the incidence and the cumulative probability of cytolytic and cholestatic hepatotoxicity during antiretroviral treatment in a group of HIV HCV haemophiliacs. We evaluated 47 patients that received 246 courses of antiretroviral treatment [98 courses of pre-highly active antiretroviral therapy (pre-HAART) and 148 HAART treatments]. Liver function tests were assessed at baseline of each treatment, after 1 month and at least every 4 months thereafter. Cytolytic and cholestatic hepatotoxicity was recorded. Of the 246 treatments, 28 (12.45%) were followed by cytolytic hepatotoxicity and 32 (13%) by cholestatic hepatotoxicity. Cytolytic hepatotoxicity was similar in HAART (16/148; 10.8%) and in pre-HAART treatment (12/98; 12.2%) and cholestatic hepatotoxicity was more frequent in HAART (29/148; 19.6%) than in pre-HAART treatment (3/98; 3.1%) (P < 0.001). The actuarial probability of developing cytolytic and cholestatic hepatotoxicity at 10 years of onset of antiretroviral treatments was 39% and 56%, respectively. Most enzyme elevations were asymptomatic, but in eight cases therapy was discontinued or changed and in one case a cirrhotic patient died of progressive liver failure. In HIV HCV haemophilia...Continue Reading

References

May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L K SchlugerH C Bodenheimer
May 18, 2000·JAMA : the Journal of the American Medical Association·M Velasco, C Guijarro
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark S SulkowskiRichard D Moore
Jan 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eugenia NegredoBonaventura Clotet
Feb 28, 2002·The American Journal of Gastroenterology·Peter M RosenbergRaymond T Chung
Jun 29, 2002·The Journal of Infectious Diseases·Ferdinand W N M WitJoep M A Lange
Mar 11, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Massimo PuotiUNKNOWN HIV-HCV Co-Infection Study Group
Apr 3, 2003·HIV Clinical Trials·Luz Martín-CarboneroVincent Soriano
Jun 12, 2003·Seminars in Liver Disease·Nickolas Kontorinis, Douglas T Dieterich

❮ Previous
Next ❯

Citations

Apr 7, 2007·Current Opinion in Gastroenterology·Cherinne Arundel, James H Lewis
Dec 17, 2009·BMC Infectious Diseases·Jaromir MiklJerry O Stern
Mar 20, 2008·World Journal of Gastroenterology : WJG·Douglas C MacDonaldThomas Powles
Aug 19, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·B A KonkleB Ewenstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.