PMID: 7335382Oct 1, 1981Paper

Hepatotoxicity of phenacetin and paracetamol in the Gunn rat

Pathology
I C CalderJ D Tange

Abstract

Both phenacetin and paracetamol produce acute centrilobular liver necrosis in the homozygous Gunn rat. Paracetamol is more hepatotoxic than phenacetin, and both are more hepatotoxic to the homozygous Gunn rat than to the heterozygous Gunn rat or to the albino rat. These findings have relevance to the role of the compounds in the clinical syndromes of paracetamol induced liver necrosis and analgesic nephropathy.

References

Jul 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K HealeyJ D Tange
Oct 18, 1971·JAMA : the Journal of the American Medical Association·T D Boyer, S L Rouff
Oct 17, 1970·British Medical Journal·K G Koutsaimanis, H E de Wardener
Apr 1, 1971·The Journal of Pathology·M F DixonL F Prescott
Jan 1, 1968·Toxicology and Applied Pharmacology·E M Boyd, S M Hottenroth

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Citations

Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J A BoutinG Siest
Nov 16, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Salman R KhetaniYvonne Will
Aug 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S M de Morais, P G Wells
Jan 1, 1983·The Journal of Pathology·M A HenryJ D Tange

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