PMID: 3214366Nov 1, 1988Paper

Hepatotoxicity to dogs of horse meat contaminated with indospicine

Australian Veterinary Journal
M P HegartyR Cameron

Abstract

An outbreak of liver disease which killed more than 30 dogs at Alice Springs was associated with feeding meat from horses, some of which had developed Indigofera linnaei poisoning (Birdsville horse disease). Affected livers were small, nodular and yellow. There was associated jaundice, ascites, elevation of alanine aminotransferase levels in serum, a tendency to bleed, and signs of hepatic encephalopathy. Histologically, livers showed periacinar necrosis, collapse and haemorrhage, with severe swelling, vacuolation and cholestasis in remaining hepatocytes. Indospicine, a toxic amino acid found in the genus Indigofera, was detected in samples of suspect horsemeat. Experimental feeding of horsemeat containing 16 mg indospicine/kg for 32 days produced periacinar necrosis and hepatocellular swelling in 2 dogs, although neither died nor showed clinical illness. In another experiment, intakes of as little as 0.13 mg indospicine/kg bodyweight/day for 70 days produced periacinar liver lesions, and indospicine concentrations in serum, muscle and liver rose during this period to 3.9, 7.9 and 17.5 mg/kg, respectively. It was concluded that meat from horses grazing I. linnaei can be hepatotoxic for dogs, and that this toxicity may be relate...Continue Reading

Citations

Feb 1, 1991·Australian Veterinary Journal·R A McKenzie
Jan 1, 1995·Australian Veterinary Journal·R A McKenzie
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·E Arthur Bell
Mar 26, 2013·Australian Veterinary Journal·S M OssedryverM T Fletcher
Feb 18, 2011·Australian Veterinary Journal·L M FitzGeraldA J O'Hara
Aug 2, 2016·Journal of Agricultural and Food Chemistry·Eddie T T TanMary T Fletcher
Aug 11, 2016·Journal of Agricultural and Food Chemistry·Eddie T T TanMary T Fletcher
Aug 31, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Eddie T T TanMary T Fletcher
Oct 30, 2016·Journal of Agricultural and Food Chemistry·Eddie T T TanMary T Fletcher
Jun 25, 2016·Organic & Biomolecular Chemistry·Cheng-Shan LangJames J De Voss
Oct 24, 2020·Toxins·Zhi Hung LohMary T Fletcher
Oct 10, 2020·The Veterinary Clinics of North America. Food Animal Practice·Bryan L StegelmeierMichael J Clayton
Mar 19, 2019·Toxicon : Official Journal of the International Society on Toxinology·Gabriele NetzelMary T Fletcher
May 2, 2003·Journal of Agricultural and Food Chemistry·E Arthur Bell

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