Hepatotrophic effect of portal blood during hepatic arterial recirculation

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
J RozgaS Bengmark

Abstract

Portal branch ligation (PBL) is known to induce a rapid and progressive atrophy in the liver parenchyma without portal blood flow and compensatory hyperplasia in the segments receiving the whole portal flow. In this study, the hepatotrophic effect of portal blood was studied in rats with PBL and after this procedure was combined with different portosystemic shunts. After 2 weeks, the most severe atrophy was found in ligated lobes of rats with PBL alone. In shunted animals, the atrophy was significantly inhibited and in relation to the magnitude of portal flow bypassed the liver. This suggests that in shunted rats, the portal-bone hepatotrophic factors undergo systemic recirculation and affect the liver by way of the hepatic artery. Simultaneously, in PBL + shunt rats, the rate of atrophy normally induced by a shunt was also dependent on the amount of portal blood available to this part of the liver. By a balance between these 2 processes, the total liver mass was maintained at the level found in sham PBL + shunt control rats.

Citations

Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M Rokicki, W Rokicki
Nov 1, 1991·Scandinavian Journal of Gastroenterology·S SkullmanJ Larsson
Jan 1, 1992·Scandinavian Journal of Gastroenterology·S SkullmanJ Larsson
Oct 1, 1991·The Journal of Surgical Research·J RozgaS Bengmark
Oct 19, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·T NobuokaK Hirata
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShimizuT Ozawa

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